Signal Transduction Antibodies 1

Anti-SLC25A12 Antibody (CAB11688)

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SKU:
CAB11688
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC25A12 Antibody
Antibody SKU:CAB11688
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SLC25A12 (NP_003696.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, U-87MG, B cells, SKOV3, HeLa, Mouse heart, Mouse brain, Mouse liver, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SLC25A12 (NP_003696.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAVK VQTT KRGD PHEL RNIF LQYA STEV DGER YMTP EDFV QRYL GLYN DPNS NPKI VQLL AGVA DQTK DGLI SYQE FLAF ESVL CAPD SMFI VAFQ LFDK SGNG EVTF ENVK EIFG QTII HHHI PFNW DCEF IRLH FGHN RKKH LNYT EFTQ FLQE LQLE HARQ AFAL KDKS KSGM ISGL
Gene ID:8604
Uniprot:O75746
Cellular Location:Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:62kDa/74kDa
Observed MW:75kDa
Synonyms:SLC25A12, AGC1, ARALAR, EIEE39
Background:This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene.
UniProt Protein Function:SLC25A12: Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. Defects in SLC25A12 are the cause of global cerebral hypomyelination (GCHM). A disorder with onset in infancy and characterized by severe psychomotor retardation, hypotonia, seizures, hypomyelination of the central nervous system, with the gray matter appearing relatively unaffected. Belongs to the mitochondrial carrier family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion

Molecular Function:acidic amino acid transmembrane transporter activity; calcium ion binding; L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity

Biological Process: aspartate transport; gluconeogenesis; L-glutamate transport; malate-aspartate shuttle; response to calcium ion

Disease: Hypomyelination, Global Cerebral

NCBI Summary:This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
UniProt Code:O75746
NCBI GenInfo Identifier:206729858
NCBI Gene ID:8604
NCBI Accession:O75746.2
UniProt Secondary Accession:O75746,Q96AM8, B3KR64,
UniProt Related Accession:O75746
Molecular Weight:75kDa
NCBI Full Name:Calcium-binding mitochondrial carrier protein Aralar1
NCBI Synonym Full Names:solute carrier family 25 member 12
NCBI Official Symbol:SLC25A12  
NCBI Official Synonym Symbols:AGC1; ARALAR; EIEE39  
NCBI Protein Information:calcium-binding mitochondrial carrier protein Aralar1
UniProt Protein Name:Calcium-binding mitochondrial carrier protein Aralar1
UniProt Synonym Protein Names:Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12
UniProt Gene Name:SLC25A12  
Anti-SLC25A12 Antibody (CAB11688)Western blot analysis of extracts of various cell lines, using SLC25A12 antibody (CAB11688) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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