Signal Transduction Antibodies 2
Anti-SLC24A2 Antibody (CAB16506)
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- SKU:
- CAB16506
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC24A2 Antibody |
| Antibody SKU: | CAB16506 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human SLC24A2 (NP_001180217.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human SLC24A2 (NP_001180217.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VKVT APEA QAKP SAAR DKDE PTLP AKPR LQRG GSSA SLHN SLMR NSIF QLMI HTLD PLAE GRFR EKAS ILHK IAKK KCHV DENE RQNG AANH VEKI ELPN S |
| Gene ID: | 25769 |
| Uniprot: | Q9UI40 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 71kDa/73kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SLC24A2, NCKX2 |
| Background: | This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SLC24A2: Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter Chromosomal Location of Human Ortholog: 9p22.1 Cellular Component: integral to membrane; plasma membrane; intrinsic to plasma membrane Molecular Function:potassium ion binding; protein dimerization activity; sodium ion binding; calcium, potassium:sodium antiporter activity; manganese ion binding; symporter activity; calcium channel activity; calcium ion binding; cadmium ion binding; nickel ion binding Biological Process: cellular calcium ion homeostasis; visual perception; response to stimulus; ion transport; learning; transmembrane transport; memory; potassium ion transport |
| NCBI Summary: | This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9UI40 |
| NCBI GenInfo Identifier: | 17865516 |
| NCBI Gene ID: | 25769 |
| NCBI Accession: | Q9UI40.1 |
| UniProt Secondary Accession: | Q9UI40,Q9NTN5, Q9NZQ4, B7ZLL8, |
| UniProt Related Accession: | Q9UI40 |
| Molecular Weight: | 71,655 Da |
| NCBI Full Name: | Sodium/potassium/calcium exchanger 2 |
| NCBI Synonym Full Names: | solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 |
| NCBI Official Symbol: | SLC24A2 |
| NCBI Official Synonym Symbols: | NCKX2 |
| NCBI Protein Information: | sodium/potassium/calcium exchanger 2; retinal cone Na-Ca+K exchanger; Na(+)/K(+)/Ca(2+)-exchange protein 2 |
| UniProt Protein Name: | Sodium/potassium/calcium exchanger 2 |
| UniProt Synonym Protein Names: | Na(+)/K(+)/Ca(2+)-exchange protein 2; Retinal cone Na-Ca+K exchanger; Solute carrier family 24 member 2 |
| Protein Family: | Sodium/potassium/calcium exchanger |
| UniProt Gene Name: | SLC24A2 |
| UniProt Entry Name: | NCKX2_HUMAN |
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