Name: Anti-SLC23A2 Antibody (CAB6740)
Brand: Signal Transduction Antibodies 3
SKU: CAB6740
Availability: OutOfStock

Antibody Name:	Anti-SLC23A2 Antibody
Antibody SKU:	CAB6740
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC23A2 (NP_976072.1).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	SKOV3, HepG2, Mouse brain, Mouse lung, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC23A2 (NP_976072.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MMGI GKNT TSKS MEAG SSTE GKYE DEAK HPAF FTLP VVIN GGAT SSGE QDNE DTEL MAIY TTEN GIAE KSSL AETL DSTG SLDP QRSD MI
Gene ID:	9962
Uniprot:	Q9UGH3
Cellular Location:	Cell membrane, Multi-pass membrane protein
Calculated MW:	58kDa/70kDa
Observed MW:	70kDa

Synonyms:	SLC23A2, NBTL1, SLC23A1, SVCT2, YSPL2, hSVCT2
Background:	The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.

UniProt Protein Function:	SLC23A2: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
UniProt Protein Details:	Protein type:Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 20p13 Cellular Component: membrane; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; basal plasma membrane Molecular Function:L-ascorbate:sodium symporter activity; sodium-dependent multivitamin transmembrane transporter activity; L-ascorbic acid transporter activity; nucleobase transmembrane transporter activity Biological Process: vitamin metabolic process; molecular hydrogen transport; sodium ion transport; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; L-ascorbic acid metabolic process; nucleobase transport; response to oxidative stress; water-soluble vitamin metabolic process; L-ascorbic acid transport
NCBI Summary:	The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UGH3
NCBI GenInfo Identifier:	24212469
NCBI Gene ID:	9962
NCBI Accession:	Q9UGH3.1
UniProt Secondary Accession:	Q9UGH3,Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85, B4DJZ1
UniProt Related Accession:	Q9UGH3
Molecular Weight:	Observed MW: 70kDaCalculated MW: 58kDa/70kDa
NCBI Full Name:	Solute carrier family 23 member 2
NCBI Synonym Full Names:	solute carrier family 23 (ascorbic acid transporter), member 2
NCBI Official Symbol:	SLC23A2
NCBI Official Synonym Symbols:	NBTL1; SVCT2; YSPL2; SLC23A1
NCBI Protein Information:	solute carrier family 23 member 2; hSVCT2; yolk sac permease-like molecule 2; Na(+)/L-ascorbic acid transporter 2; nucleobase transporter-like 1 protein; sodium-dependent vitamin C transporter-2; solute carrier family 23 (nucleobase transporters), member 1; solute carrier family 23 (nucleobase transporters), member 2
UniProt Protein Name:	Solute carrier family 23 member 2
UniProt Synonym Protein Names:	Na(+)/L-ascorbic acid transporter 2; Nucleobase transporter-like 1 protein; Sodium-dependent vitamin C transporter 2; hSVCT2; Yolk sac permease-like molecule 2
Protein Family:	Solute carrier family
UniProt Gene Name:	SLC23A2
UniProt Entry Name:	S23A2_HUMAN

	Western blot analysis of extracts of various cell lines, using SLC23A2 antibody (CAB6740) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunofluorescence analysis of MCF7 cells using SLC23A2 antibody (CAB6740).