Signal Transduction Antibodies 1

Anti-SLC23A1 Antibody (CAB10276)

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SKU:
CAB10276
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC23A1 Antibody
Antibody SKU:CAB10276
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 512-598 of human SLC23A1 (NP_005838.3).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:293T, A-549, SKOV3, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 512-598 of human SLC23A1 (NP_005838.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DNTV PGSP EERG LIQW KAGA HANS DMSS SLKS YDFP IGMG IVKR ITFL KYIP ICPV FKGF SSSS KDQI AIPE DTPE NTET ASVC TKV
Gene ID:9963
Uniprot:Q9UHI7
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:28kDa/64kDa/65kDa
Observed MW:80kDa
Synonyms:SLC23A1, SLC23A2, SVCT1, YSPL3
Background:The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:SLC23A1: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: apical plasma membrane; cytoplasm; integral to plasma membrane; intracellular organelle; membrane; plasma membrane

Molecular Function:dehydroascorbic acid transporter activity; L-ascorbate:sodium symporter activity; L-ascorbic acid transporter activity; nucleobase transmembrane transporter activity; protein binding; sodium ion transmembrane transporter activity

Biological Process: brain development; L-ascorbic acid metabolic process; L-ascorbic acid transport; nucleobase transport; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; response to toxin; sodium ion transport

NCBI Summary:The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Code:Q9UHI7
NCBI GenInfo Identifier:296452969
NCBI Gene ID:9963
NCBI Accession:Q9UHI7.3
UniProt Secondary Accession:Q9UHI7,O95191, Q8WWB6, Q9UGH4, Q9UI39,
UniProt Related Accession:Q9UHI7
Molecular Weight:28,531 Da
NCBI Full Name:Solute carrier family 23 member 1
NCBI Synonym Full Names:solute carrier family 23 member 1
NCBI Official Symbol:SLC23A1  
NCBI Official Synonym Symbols:SVCT1; YSPL3; SLC23A2  
NCBI Protein Information:solute carrier family 23 member 1
UniProt Protein Name:Solute carrier family 23 member 1
UniProt Synonym Protein Names:Na(+)/L-ascorbic acid transporter 1; Sodium-dependent vitamin C transporter 1; hSVCT1; Yolk sac permease-like molecule 3
Protein Family:Solute carrier family
UniProt Gene Name:SLC23A1  
UniProt Entry Name:S23A1_HUMAN
Anti-SLC23A1 Antibody (CAB10276)Western blot analysis of extracts of various cell lines, using SLC23A1 antibody (CAB10276) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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