Signal Transduction Antibodies 2
Anti-SLC22A7 Antibody (CAB15137)
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- SKU:
- CAB15137
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC22A7 Antibody |
| Antibody SKU: | CAB15137 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-142 of human SLC22A7 (NP_696961.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, HT-29, mouse liver, mouse kidney, rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-142 of human SLC22A7 (NP_696961.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALPG APAN FSHQ DVWL EAHL PREP DGTL SSCL RFAY PQAL PNTT LGEE RQSR GELE DEPA TVPC SQGW EYDH SEFS STIA TESQ WDLV CEQK G |
| Gene ID: | 10864 |
| Uniprot: | Q9Y694 |
| Cellular Location: | Basolateral cell membrane, Multi-pass membrane protein |
| Calculated MW: | 26kDa/59kDa/60kDa |
| Observed MW: | 60kDa |
| Synonyms: | SLC22A7, NLT, OAT2, hOAT11 |
| Background: | The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. |
| UniProt Protein Function: | SLC22A7: Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: membrane; basolateral plasma membrane; integral to plasma membrane; plasma membrane Molecular Function:sodium-independent organic anion transmembrane transporter activity Biological Process: transmembrane transport; organic anion transport |
| NCBI Summary: | The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y694 |
| NCBI GenInfo Identifier: | 74753520 |
| NCBI Gene ID: | 10864 |
| NCBI Accession: | Q9Y694.1 |
| UniProt Related Accession: | Q9Y694 |
| Molecular Weight: | 60kDa |
| NCBI Full Name: | Solute carrier family 22 member 7 |
| NCBI Synonym Full Names: | solute carrier family 22 member 7 |
| NCBI Official Symbol: | SLC22A7 |
| NCBI Official Synonym Symbols: | NLT; OAT2; hOAT11 |
| NCBI Protein Information: | solute carrier family 22 member 7 |
| UniProt Protein Name: | Solute carrier family 22 member 7 |
| UniProt Synonym Protein Names: | Novel liver transporter; Organic anion transporter 2; hOAT2 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC22A7 |
| UniProt Entry Name: | S22A7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC22A7 antibody (CAB15137) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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