Cell Biology Antibodies 7
Anti-SLC22A6 Antibody (CAB1814)
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- SKU:
- CAB1814
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SLC22A6 Antibody |
| Antibody SKU: | CAB1814 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SLC22A6 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | 293T, LO2, U2OS, HT-1080, HT-29, Rat kidney |
| Immunogen: | Recombinant protein of human SLC22A6 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9356 |
| Uniprot: | Q4U2R8 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 55kDa/57kDa/60kDa/61kDa |
| Observed MW: | 62kDa |
| Synonyms: | SLC22A6, HOAT1, OAT1, PAHT, ROAT1 |
| Background: | The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. |
| UniProt Protein Function: | SLC22A6: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid. PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family Chromosomal Location of Human Ortholog: 11q12.3 Cellular Component: protein complex; basolateral plasma membrane; integral to plasma membrane; plasma membrane; caveola Molecular Function:protein binding; protein homodimerization activity; inorganic anion exchanger activity; organic anion transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; chloride ion binding Biological Process: sodium-independent organic anion transport; alpha-ketoglutarate transport; response to methotrexate; transmembrane transport; protein homooligomerization; organic anion transport |
| NCBI Summary: | The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q4U2R8 |
| NCBI GenInfo Identifier: | 74762955 |
| NCBI Gene ID: | 9356 |
| NCBI Accession: | Q4U2R8.1 |
| UniProt Secondary Accession: | Q4U2R8,O95187, O95742, Q7LDA0, Q8N192, Q9NQA6, Q9NQC2 Q9UBG6, Q9UEQ8, A8MY93, B2D0R6, |
| UniProt Related Accession: | Q4U2R8 |
| Molecular Weight: | 563 |
| NCBI Full Name: | Solute carrier family 22 member 6 |
| NCBI Synonym Full Names: | solute carrier family 22 (organic anion transporter), member 6 |
| NCBI Official Symbol: | SLC22A6 |
| NCBI Official Synonym Symbols: | OAT1; PAHT; HOAT1; ROAT1 |
| NCBI Protein Information: | solute carrier family 22 member 6; hPAHT; hROAT1; PAH transporter; organic anion transporter 1; para-aminohippurate transporter; renal organic anion transporter 1 |
| UniProt Protein Name: | Solute carrier family 22 member 6 |
| UniProt Synonym Protein Names: | Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; hROAT1 |
| UniProt Gene Name: | SLC22A6 |
| UniProt Entry Name: | S22A6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC22A6 antibody (CAB1814) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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