Name: Anti-SLC22A2 Antibody (CAB8453)
Brand: Signal Transduction Antibodies 3
SKU: CAB8453
Availability: OutOfStock

Antibody Name:	Anti-SLC22A2 Antibody
Antibody SKU:	CAB8453
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 44-140 of human SLC22A2 (NP_003049.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Rat
Positive Samples:	Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 44-140 of human SLC22A2 (NP_003049.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	GFTP DHRC RSPG VAEL SLRC GWSP AEEL NYTV PGPG PAGE ASPR QCRR YEVD WNQS TFDC VDPL ASLD TNRS RLPL GPCR DGWV YETP GSSI VTEF N
Gene ID:	6582
Uniprot:	O15244
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	26kDa/54kDa/62kDa
Observed MW:	80kDa

Synonyms:

SLC22A2, 43010, OCT2

Background:

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.

UniProt Protein Function:	SLC22A2: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: membrane; plasma membrane Molecular Function:choline transmembrane transporter activity; dopamine transmembrane transporter activity; neurotransmitter transporter activity; organic cation transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity Biological Process: body fluid secretion; choline transport; dopamine transport; multidrug transport; neurotransmitter biosynthetic process; neurotransmitter secretion; organic cation transport
NCBI Summary:	Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
UniProt Code:	O15244
NCBI GenInfo Identifier:	313104182
NCBI Gene ID:	6582
NCBI Accession:	O15244.2
UniProt Secondary Accession:	O15244,Q5T7Q6, Q6PIQ8, Q8NG62, Q9NQB9,
UniProt Related Accession:	O15244
Molecular Weight:	26,685 Da
NCBI Full Name:	Solute carrier family 22 member 2
NCBI Synonym Full Names:	solute carrier family 22 member 2
NCBI Official Symbol:	SLC22A2
NCBI Official Synonym Symbols:	OCT2
NCBI Protein Information:	solute carrier family 22 member 2
UniProt Protein Name:	Solute carrier family 22 member 2
UniProt Synonym Protein Names:	Organic cation transporter 2; hOCT2
Protein Family:	Solute carrier family
UniProt Gene Name:	SLC22A2
UniProt Entry Name:	S22A2_HUMAN

Anti-SLC22A2 Polyclonal Antibody (CAB8453)

Western blot analysis of extracts of rat brain, using SLC22A2 antibody (CAB8453) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

Anti-SLC22A2 Antibody (CAB14061)

SLC22A2 Antibody (PACO12255)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)