Signal Transduction Antibodies 1

Anti-SLC22A2 Antibody (CAB14061)

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SKU:
CAB14061
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC22A2 Antibody
Antibody SKU:CAB14061
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 44-140 of human SLC22A2 (NP_003049.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 44-140 of human SLC22A2 (NP_003049.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GFTP DHRC RSPG VAEL SLRC GWSP AEEL NYTV PGPG PAGE ASPR QCRR YEVD WNQS TFDC VDPL ASLD TNRS RLPL GPCR DGWV YETP GSSI VTEF N
Gene ID:6582
Uniprot:O15244
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:26kDa/54kDa/62kDa
Observed MW:95kDa
Synonyms:SLC22A2, 43010, OCT2
Background:Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.
UniProt Protein Function:SLC22A2: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: membrane; plasma membrane

Molecular Function:choline transmembrane transporter activity; dopamine transmembrane transporter activity; neurotransmitter transporter activity; organic cation transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity

Biological Process: body fluid secretion; choline transport; dopamine transport; multidrug transport; neurotransmitter biosynthetic process; neurotransmitter secretion; organic cation transport

NCBI Summary:Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
UniProt Code:O15244
NCBI GenInfo Identifier:313104182
NCBI Gene ID:6582
NCBI Accession:O15244.2
UniProt Secondary Accession:O15244,Q5T7Q6, Q6PIQ8, Q8NG62, Q9NQB9,
UniProt Related Accession:O15244
Molecular Weight:26,685 Da
NCBI Full Name:Solute carrier family 22 member 2
NCBI Synonym Full Names:solute carrier family 22 member 2
NCBI Official Symbol:SLC22A2  
NCBI Official Synonym Symbols:OCT2  
NCBI Protein Information:solute carrier family 22 member 2
UniProt Protein Name:Solute carrier family 22 member 2
UniProt Synonym Protein Names:Organic cation transporter 2; hOCT2
Protein Family:Solute carrier family
UniProt Gene Name:SLC22A2  
UniProt Entry Name:S22A2_HUMAN
Anti-SLC22A2 Antibody (CAB14061)Western blot analysis of extracts of mouse kidney, using SLC22A2 antibody (CAB14061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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