Signal Transduction Antibodies 1
Anti-SLC22A2 Antibody (CAB14061)
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- SKU:
- CAB14061
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC22A2 Antibody |
| Antibody SKU: | CAB14061 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 44-140 of human SLC22A2 (NP_003049.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 44-140 of human SLC22A2 (NP_003049.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GFTP DHRC RSPG VAEL SLRC GWSP AEEL NYTV PGPG PAGE ASPR QCRR YEVD WNQS TFDC VDPL ASLD TNRS RLPL GPCR DGWV YETP GSSI VTEF N |
| Gene ID: | 6582 |
| Uniprot: | O15244 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 26kDa/54kDa/62kDa |
| Observed MW: | 95kDa |
| Synonyms: | SLC22A2, 43010, OCT2 |
| Background: | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. |
| UniProt Protein Function: | SLC22A2: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: membrane; plasma membrane Molecular Function:choline transmembrane transporter activity; dopamine transmembrane transporter activity; neurotransmitter transporter activity; organic cation transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity Biological Process: body fluid secretion; choline transport; dopamine transport; multidrug transport; neurotransmitter biosynthetic process; neurotransmitter secretion; organic cation transport |
| NCBI Summary: | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15244 |
| NCBI GenInfo Identifier: | 313104182 |
| NCBI Gene ID: | 6582 |
| NCBI Accession: | O15244.2 |
| UniProt Secondary Accession: | O15244,Q5T7Q6, Q6PIQ8, Q8NG62, Q9NQB9, |
| UniProt Related Accession: | O15244 |
| Molecular Weight: | 26,685 Da |
| NCBI Full Name: | Solute carrier family 22 member 2 |
| NCBI Synonym Full Names: | solute carrier family 22 member 2 |
| NCBI Official Symbol: | SLC22A2 |
| NCBI Official Synonym Symbols: | OCT2 |
| NCBI Protein Information: | solute carrier family 22 member 2 |
| UniProt Protein Name: | Solute carrier family 22 member 2 |
| UniProt Synonym Protein Names: | Organic cation transporter 2; hOCT2 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC22A2 |
| UniProt Entry Name: | S22A2_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using SLC22A2 antibody (CAB14061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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