Immunology Antibodies 2

Anti-SLC20A2 Antibody (CAB6739)

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SKU:
CAB6739
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-SLC20A2 Antibody
Antibody SKU:CAB6739
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 235-485 of human SLC20A2 (NP_001244110.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:10 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, HepG2, Mouse liver, Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 235-485 of human SLC20A2 (NP_001244110.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CPWM RRKI TGKL QKEG ALSR VSDE SLSK VQEA ESPV FKEL PGAK ANDD STIP LTGA AGET LGTS EGTS AGSH PRAA YGRA LSMT HGSV KSPI SNGT FGFD GHTR SDGH VYHT VHKD SGLY KDLL HKIH IDRG PEEK PAQE SNYR LLRR NNSY TCYT AAIC GLPV HATF RAAD SSAP EDSE KLVG DTVS YSKK RLRY DSYS SYCN AVAE AEIE AEEG GVEM KLAS ELAD PDQP REDP AEEE KEEK DAPE VHL
Gene ID:6575
Uniprot:Q08357
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:70kDa
Observed MW:70kDa
Synonyms:SLC20A2, GLVR-2, GLVR2, IBGC1, IBGC3, MLVAR, PIT-2, PIT2, RAM1, Ram-1
Background:This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:SLC20A2: Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. Defects in SLC20A2 are the cause of basal ganglia calcification, idiopathic, type 3 (IBGC3). An autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
UniProt Protein Details:

Protein type:Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 8p11.21

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function:viral receptor activity; receptor activity; sodium:phosphate symporter activity; inorganic phosphate transmembrane transporter activity

Biological Process: entry of virus into host cell; transport; ion transport; transmembrane transport

Disease: Basal Ganglia Calcification, Idiopathic, 1

NCBI Summary:This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
UniProt Code:Q08357
NCBI GenInfo Identifier:74735615
NCBI Gene ID:6575
NCBI Accession:Q08357.1
UniProt Related Accession:Q08357
Molecular Weight:70kDa
NCBI Full Name:Sodium-dependent phosphate transporter 2
NCBI Synonym Full Names:solute carrier family 20 member 2
NCBI Official Symbol:SLC20A2  
NCBI Official Synonym Symbols:PIT2; RAM1; GLVR2; IBGC1; IBGC3; MLVAR; PIT-2; Ram-1; GLVR-2  
NCBI Protein Information:sodium-dependent phosphate transporter 2
UniProt Protein Name:Sodium-dependent phosphate transporter 2
UniProt Synonym Protein Names:Gibbon ape leukemia virus receptor 2; GLVR-2; Phosphate transporter 2; PiT-2; Pit2; hPit2; Solute carrier family 20 member 2
Protein Family:Sodium-dependent phosphate transporter
UniProt Gene Name:SLC20A2  
UniProt Entry Name:S20A2_HUMAN
Anti-SLC20A2 Antibody (CAB6739)Western blot analysis of extracts of various cell lines, using SLC20A2 antibody (CAB6739) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-SLC20A2 Antibody (CAB6739)Immunofluorescence analysis of HeLa cells using SLC20A2 antibody (CAB6739). Blue: DAPI for nuclear staining.
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