Signal Transduction Antibodies 3
Anti-SLC1A5 Antibody (CAB6981)
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- SKU:
- CAB6981
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC1A5 Antibody |
| Antibody SKU: | CAB6981 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 154-224 of human SLC1A5 (NP_005619.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:3000 |
| Reactivity: | Human |
| Positive Samples: | NCI-H460, U-251MG, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 154-224 of human SLC1A5 (NP_005619.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QPGA ASAA INAS VGAA GSAE NAPS KEVL DSFL DLAR NIFP SNLV SAAF RSYS TTYE ERNI TGTR VKVP VGQ |
| Gene ID: | 6510 |
| Uniprot: | Q15758 |
| Cellular Location: | Cell membrane, Melanosome, Multi-pass membrane protein |
| Calculated MW: | 33kDa/36kDa/56kDa |
| Observed MW: | 50kDa |
| Synonyms: | SLC1A5, AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC |
| Background: |
| UniProt Protein Function: | SLC1A5: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses. Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily. 1 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: Golgi apparatus; integral to plasma membrane; membrane; plasma membrane Molecular Function:amino acid transmembrane transporter activity; L-glutamine transmembrane transporter activity; neutral amino acid transmembrane transporter activity; protein binding; receptor activity Biological Process: amino acid transport; glutamine transport; neutral amino acid transport |
| NCBI Summary: | The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | Q15758 |
| NCBI GenInfo Identifier: | 21542389 |
| NCBI Gene ID: | 6510 |
| NCBI Accession: | Q15758.2 |
| UniProt Secondary Accession: | Q15758,O95720, Q96RL9, Q9BWQ3, Q9UNP2, A8K9H5, B4DR77 B4DWS4, B7ZB81, D0EYG6, E9PC01, |
| UniProt Related Accession: | Q15758 |
| Molecular Weight: | 33,710 Da |
| NCBI Full Name: | Neutral amino acid transporter B(0) |
| NCBI Synonym Full Names: | solute carrier family 1 member 5 |
| NCBI Official Symbol: | SLC1A5 |
| NCBI Official Synonym Symbols: | R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1 |
| NCBI Protein Information: | neutral amino acid transporter B(0) |
| UniProt Protein Name: | Neutral amino acid transporter B(0) |
| UniProt Synonym Protein Names: | Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 |
| Protein Family: | Neutral amino acid transporter |
| UniProt Gene Name: | SLC1A5 |
| UniProt Entry Name: | AAAT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC1A5 antibody (CAB6981) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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