Name: Anti-SLC1A4 Antibody (CAB12507)
Brand: Signal Transduction Antibodies 1
SKU: CAB12507
Availability: OutOfStock

Antibody Name:	Anti-SLC1A4 Antibody
Antibody SKU:	CAB12507
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 140-220 of human SLC1A4 (NP_003029.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Raji, SW480, BT-474, Mouse brain, Mouse kidney, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 140-220 of human SLC1A4 (NP_003029.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	KPGS GAQT LQSS DLGL EDSG PPPV PKET VDSF LDLA RNLF PSNL VVAA FRTY ATDY KVVT QNSS SGNV THEK IPIG TEIE G
Gene ID:	6509
Uniprot:	P43007
Cellular Location:	Melanosome, Membrane, Multi-pass membrane protein
Calculated MW:	24kDa/55kDa
Observed MW:	53kDa

Synonyms:	SLC1A4, ASCT1, SATT, SPATCCM
Background:	The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability.

UniProt Protein Function:	SLC1A4: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral Chromosomal Location of Human Ortholog: 2p15-p13 Cellular Component: centrosome; cell surface; cell soma; membrane; integral to plasma membrane; dendrite; melanosome; integral to membrane; plasma membrane; intermediate filament; microtubule organizing center Molecular Function:L-serine transmembrane transporter activity; chloride channel activity; L-threonine transmembrane transporter activity; L-proline transmembrane transporter activity; L-alanine transmembrane transporter activity; L-glutamine transmembrane transporter activity; L-cystine transmembrane transporter activity; sodium:dicarboxylate symporter activity Biological Process: synaptic transmission, glutamatergic; threonine transport; L-cystine transport; chloride transport; L-serine transport; L-alanine transport; dicarboxylic acid transport; amino acid transport; ion transport; cognition; proline transport; glutamine transport; transmembrane transport
NCBI Summary:	The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. [provided by RefSeq, Jan 2017]
UniProt Code:	P43007
NCBI GenInfo Identifier:	1173365
NCBI Gene ID:	6509
NCBI Accession:	P43007.1
UniProt Related Accession:	P43007
Molecular Weight:	~56kDa
NCBI Full Name:	Neutral amino acid transporter A
NCBI Synonym Full Names:	solute carrier family 1 member 4
NCBI Official Symbol:	SLC1A4
NCBI Official Synonym Symbols:	SATT; ASCT1; SPATCCM
NCBI Protein Information:	neutral amino acid transporter A
UniProt Protein Name:	Neutral amino acid transporter A
UniProt Synonym Protein Names:	Alanine/serine/cysteine/threonine transporter 1; ASCT-1; SATT; Solute carrier family 1 member 4
Protein Family:	Neutral amino acid transporter
UniProt Gene Name:	SLC1A4
UniProt Entry Name:	SATT_HUMAN

	Western blot analysis of extracts of various cell lines, using SLC1A4 antibody (CAB12507) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
	Immunohistochemistry of paraffin-embedded rat brain using SLC1A4 antibody (CAB12507) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse testis using SLC1A4 antibody (CAB12507) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse spinal cord using SLC1A4 antibody (CAB12507) at dilution of 1:100 (40x lens).