Signal Transduction Antibodies 1
Anti-SLC19A1 Antibody (CAB14644)
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- SKU:
- CAB14644
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC19A1 Antibody |
| Antibody SKU: | CAB14644 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 452-591 of human SLC19A1 (NP_919231.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 452-591 of human SLC19A1 (NP_919231.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LDGL RHCQ RGHH PRQP PAQG LRSA AEEK AAQA LSVQ DKGL GGLQ PAQS PPLS PEDS LGAV GPAS LEQR QSDP YLAQ APAP QAAE FLSP VTTP SPCT LCSA QASG PEAA DETC PQLA VHPP GVSK LGLQ CLPS DGVQ NVNQ |
| Gene ID: | 6573 |
| Uniprot: | P41440 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 54kDa/60kDa/64kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SLC19A1, CHMD, FOLT, IFC1, REFC, RFC1 |
| Background: | The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SLC19A1: a transporter protein. Transports reduced folate, antitumor agents and folate antagonists such as methotrexate. Apparently involved in methotrexate resistance in various cancers and neural tube defects. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: apical plasma membrane; basolateral plasma membrane; plasma membrane Molecular Function:folic acid binding; folic acid transporter activity; methotrexate transporter activity; reduced folate carrier activity Biological Process: folic acid metabolic process; folic acid transport; methotrexate transport |
| NCBI Summary: | The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
| UniProt Code: | P41440 |
| NCBI GenInfo Identifier: | 12643280 |
| NCBI Gene ID: | 6573 |
| NCBI Accession: | P41440.3 |
| UniProt Secondary Accession: | P41440,O00553, O60227, Q13026, Q9BTX8, B2R7U8, B7Z8C3 E9PFY4, |
| UniProt Related Accession: | P41440 |
| Molecular Weight: | Calculated MW: 54kDa/60kDa/64kDaObserved MW: 65kDa |
| NCBI Full Name: | Folate transporter 1 |
| NCBI Synonym Full Names: | solute carrier family 19 member 1 |
| NCBI Official Symbol: | SLC19A1 |
| NCBI Official Synonym Symbols: | CHMD; FOLT; IFC1; REFC; RFC1 |
| NCBI Protein Information: | folate transporter 1 |
| UniProt Protein Name: | Folate transporter 1 |
| UniProt Synonym Protein Names: | Intestinal folate carrier 1; IFC-1; Placental folate transporter; Reduced folate carrier protein; RFC; Solute carrier family 19 member 1 |
| UniProt Gene Name: | SLC19A1 |
 | Immunohistochemistry of paraffin-embedded human liver using SLC19A1 antibody (CAB14644) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat heart using SLC19A1 antibody (CAB14644) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using SLC19A1 antibody (CAB14644) at dilution of 1:100 (40x lens). |
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