Neuroscience
Anti-SLC18A3 Antibody (CAB16068)
- SKU:
- CAB16068
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-SLC18A3 Antibody |
| Antibody SKU: | CAB16068 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SLC18A3 (NP_003046.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SLC18A3 (NP_003046.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MESA EPAG QARA AATK LSEA VGAA LQEP RRQR RLVL VIVC VALL LDNM LYMV IVPI VPDY IAHM RGGG EGPT RTPE VWEP TLPL PTPA NASA YTAN TSAS PTAA WPAG SALR PRYP TESE DVKI GVLF ASKA ILQL LVNP LSGP FIDR MS |
| Gene ID: | 6572 |
| Uniprot: | Q16572 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 56kDa |
| Observed MW: | 65KDa |
| Synonyms: | SLC18A3, CMS21, VACHT |
| Background: | This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. |
| UniProt Protein Function: | SLC18A3: Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. |
| UniProt Protein Details: | Protein type:Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: membrane; integral to plasma membrane; plasma membrane Molecular Function:acetylcholine transmembrane transporter activity Biological Process: synaptic transmission; acetylcholine transport; neurotransmitter secretion |
| NCBI Summary: | This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16572 |
| NCBI GenInfo Identifier: | 118582257 |
| NCBI Gene ID: | 6572 |
| NCBI Accession: | NP_003046.2 |
| UniProt Secondary Accession: | Q16572,B2R7S1, |
| UniProt Related Accession: | Q16572 |
| Molecular Weight: | 56,903 Da |
| NCBI Full Name: | vesicular acetylcholine transporter |
| NCBI Synonym Full Names: | solute carrier family 18 (vesicular acetylcholine transporter), member 3 |
| NCBI Official Symbol: | SLC18A3 |
| NCBI Official Synonym Symbols: | VACHT |
| NCBI Protein Information: | vesicular acetylcholine transporter |
| UniProt Protein Name: | Vesicular acetylcholine transporter |
| UniProt Synonym Protein Names: | Solute carrier family 18 member 3 |
| Protein Family: | Vesicular acetylcholine transporter |
| UniProt Gene Name: | SLC18A3 |
| UniProt Entry Name: | VACHT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC18A3 Polyclonal Antibody (CAB16068) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat brain using SLC18A3 antibody (CAB16068) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of mouse brain using SLC18A3 Rabbit pAb (CAB16068) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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