| UniProt Protein Function: | SLC18A2: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Belongs to the major facilitator superfamily. Vesicular transporter family. |
| UniProt Protein Details: | Protein type:Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 10q25 Cellular Component: synaptic vesicle; synaptic vesicle membrane; membrane; cell soma; integral to plasma membrane; plasma membrane; terminal button Molecular Function:serotonin transmembrane transporter activity; enzyme binding; amine transmembrane transporter activity; heat shock protein binding; monoamine transmembrane transporter activity; drug binding Biological Process: dopamine transport; neurotransmitter secretion; death; amine transport; response to amphetamine; monoamine transport; locomotory behavior; response to herbicide; glucose homeostasis; endocytic recycling; response to cocaine; sequestering of neurotransmitter; post-embryonic development; response to starvation; synaptic transmission; insulin secretion; response to zinc ion; serotonin transport; transmembrane transport; negative regulation of neurotransmitter transport; aging; response to corticosterone stimulus |
| NCBI Summary: | This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. [provided by RefSeq, Jun 2018] |
| UniProt Code: | Q05940 |
| NCBI GenInfo Identifier: | 1722742 |
| NCBI Gene ID: | 6571 |
| NCBI Accession: | Q05940.2 |
| UniProt Related Accession: | Q05940 |
| Molecular Weight: | |
| NCBI Full Name: | Synaptic vesicular amine transporter |
| NCBI Synonym Full Names: | solute carrier family 18 member A2 |
| NCBI Official Symbol: | SLC18A2 |
| NCBI Official Synonym Symbols: | SVAT; SVMT; VAT2; VMAT2; PKDYS2 |
| NCBI Protein Information: | synaptic vesicular amine transporter |
| UniProt Protein Name: | Synaptic vesicular amine transporter |
| UniProt Synonym Protein Names: | Monoamine transporter; Solute carrier family 18 member 2; Vesicular amine transporter 2; VAT2 |
| UniProt Gene Name: | SLC18A2 |
| UniProt Entry Name: | VMAT2_HUMAN |
