Name: Anti-SLC17A7 Antibody (CAB12879)
Brand: Signal Transduction Antibodies 1
SKU: CAB12879
Availability: OutOfStock

Antibody Name:	Anti-SLC17A7 Antibody
Antibody SKU:	CAB12879
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 461-560 of human SLC17A7 (NP_064705.1).

Application:	WB
Recommended Dilution:	WB 1:200 - 1:2000
Reactivity:	Human
Positive Samples:	SH-SY5Y

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 461-560 of human SLC17A7 (NP_064705.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	KHKT REEW QYVF LIAS LVHY GGVI FYGV FASG EKQP WAEP EEMS EEKC GFVG HDQL AGSD DSEM EDEA EPPG APPA PPPS YGAT HSTF QPPR PPPP VRDY
Gene ID:	57030
Uniprot:	Q9P2U7
Cellular Location:	Cell junction, Cytoplasmic vesicle, Membrane, Multi-pass membrane protein, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome
Calculated MW:	53kDa/59kDa/61kDa
Observed MW:	62kDa

Synonyms:

SLC17A7, BNPI, VGLUT1

Background:

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.

UniProt Protein Function:	SLC17A7: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
UniProt Protein Details:	Protein type:Transporter, SLC family; Membrane protein, multi-pass; Vesicle; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 19q13 Cellular Component: synaptic vesicle membrane; integral to membrane; presynaptic active zone; plasma membrane; excitatory synapse; cell junction Molecular Function:sodium:inorganic phosphate symporter activity; sodium-dependent phosphate transmembrane transporter activity; inorganic phosphate transmembrane transporter activity; L-glutamate transmembrane transporter activity Biological Process: synaptic transmission; synaptic transmission, glutamatergic; L-glutamate import; glutamate secretion; phosphate transport; long-term memory; neurotransmitter secretion; ion transport; regulation of excitatory postsynaptic membrane potential; sequestering of neurotransmitter; transmembrane transport
NCBI Summary:	The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9P2U7
NCBI GenInfo Identifier:	9945322
NCBI Gene ID:	57030
NCBI Accession:	NP_064705.1
UniProt Related Accession:	Q9P2U7
Molecular Weight:	61kDa
NCBI Full Name:	vesicular glutamate transporter 1
NCBI Synonym Full Names:	solute carrier family 17 member 7
NCBI Official Symbol:	SLC17A7
NCBI Official Synonym Symbols:	BNPI; VGLUT1
NCBI Protein Information:	vesicular glutamate transporter 1
UniProt Protein Name:	Vesicular glutamate transporter 1
UniProt Synonym Protein Names:	Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7
UniProt Gene Name:	SLC17A7
UniProt Entry Name:	VGLU1_HUMAN

Western blot analysis of extracts of SH-SY5Y cells, using SLC17A7 antibody (CAB12879) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

Anti-SLC17A7 Antibody (CAB17188)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)