Signal Transduction Antibodies 1
Anti-SLC16A7 Antibody (CAB12386)
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- SKU:
- CAB12386
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLC16A7 Antibody |
| Antibody SKU: | CAB12386 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human SLC16A7 (NP_001257551.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, HL-60, Mouse kidney, Rat testis, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human SLC16A7 (NP_001257551.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TGEY KYMY MSCG AIVV AASV WLLI GNAI NYRL LAKE RKEE NARQ KTRE SEPL SKSK HSED VNVK VSNA QSVT SERE TNI |
| Gene ID: | 9194 |
| Uniprot: | O60669 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 52kDa |
| Observed MW: | 45kDa |
| Synonyms: | SLC16A7, MCT2 |
| Background: | This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SLC16A7: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q13 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:pyruvate secondary active transmembrane transporter activity; symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity; pyruvate transmembrane transporter activity Biological Process: transmembrane transport |
| NCBI Summary: | This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
| UniProt Code: | O60669 |
| NCBI GenInfo Identifier: | 313104141 |
| NCBI Gene ID: | 9194 |
| NCBI Accession: | O60669.2 |
| UniProt Related Accession: | O60669 |
| Molecular Weight: | |
| NCBI Full Name: | Monocarboxylate transporter 2 |
| NCBI Synonym Full Names: | solute carrier family 16 member 7 |
| NCBI Official Symbol: | SLC16A7 |
| NCBI Official Synonym Symbols: | MCT2 |
| NCBI Protein Information: | monocarboxylate transporter 2 |
| UniProt Protein Name: | Monocarboxylate transporter 2 |
| UniProt Synonym Protein Names: | Solute carrier family 16 member 7 |
| Protein Family: | Molybdate transporter |
| UniProt Gene Name: | SLC16A7 |
| UniProt Entry Name: | MOT2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC16A7 antibody (CAB12386) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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