Signal Transduction Antibodies 1

Anti-SLC15A1 Antibody (CAB10246)

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SKU:
CAB10246
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC15A1 Antibody
Antibody SKU:CAB10246
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 600-700 of human SLC15A1 (NP_005064.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse lung, Rat testis
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 600-700 of human SLC15A1 (NP_005064.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VTGL EFSY SQAP SNMK SVLQ AGWL LTVA VGNI IVLI VAGA GQFS KQWA EYIL FAAL LLVV CVIF AIMA RFYT YINP AEIE AQFD EDEK KNRL EKSN PYFM S
Gene ID:6564
Uniprot:P46059
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:78kDa
Observed MW:78kDa
Synonyms:SLC15A1, HPECT1, HPEPT1, PEPT1
Background:This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.
UniProt Protein Function:SLC15A1: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products. Belongs to the PTR2/POT transporter (TC 2.A.17) family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 13q32.2-q32.3

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function:peptide:hydrogen symporter activity

Biological Process: digestion; ion transport; transport

NCBI Summary:This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]
UniProt Code:P46059
NCBI GenInfo Identifier:1172435
NCBI Gene ID:6564
NCBI Accession:P46059.1
UniProt Secondary Accession:P46059,Q5VW82,
UniProt Related Accession:P46059
Molecular Weight:79kDa
NCBI Full Name:Solute carrier family 15 member 1
NCBI Synonym Full Names:solute carrier family 15 member 1
NCBI Official Symbol:SLC15A1  
NCBI Official Synonym Symbols:PEPT1; HPECT1; HPEPT1  
NCBI Protein Information:solute carrier family 15 member 1
UniProt Protein Name:Solute carrier family 15 member 1
UniProt Synonym Protein Names:Intestinal H(+)/peptide cotransporter; Oligopeptide transporter, small intestine isoform; Peptide transporter 1
Protein Family:Solute carrier family
UniProt Gene Name:SLC15A1  
Anti-SLC15A1 Antibody (CAB10246)Western blot analysis of extracts of various cell lines, using SLC15A1 antibody (CAB10246) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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