Signal Transduction Antibodies 1

Anti-SLC14A2 Antibody (CAB13208)

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SKU:
CAB13208
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC14A2 Antibody
Antibody SKU:CAB13208
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 420-580 of human SLC14A2 (NP_009094.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, K-562, LO2, Mouse testis, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 420-580 of human SLC14A2 (NP_009094.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FRLP LSKV TYPE ANRI YYLT VKSG EEEK APSG GGGE HPPT AGPK VEEG SEAV LSKH RSVF HIEW SSIR RRSK VFGK GEHQ ERQN KDPF PYRY RKPT VELL DLDT MEES SEIK VETN ISKT SWIR SSMA ASGK RVSK ALSY ITGE MKEC GEGL KDKS PVFQ F
Gene ID:8170
Uniprot:Q15849
Cellular Location:Apical cell membrane, Multi-pass membrane protein
Calculated MW:43kDa/101kDa
Observed MW:101kDa
Synonyms:SLC14A2, HUT2, UT-A2, UT2, UTA, UTR, hUT-A6
Background:The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:SLC14A2: Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Belongs to the urea transporter family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q12.1-q21.1

Cellular Component: membrane; apical plasma membrane; integral to membrane; plasma membrane

Molecular Function:protein binding; urea transmembrane transporter activity; cell adhesion molecule binding

Biological Process: urea transport; transmembrane transport

NCBI Summary:The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:Q15849
NCBI GenInfo Identifier:336594532
NCBI Gene ID:8170
NCBI Accession:NP_001229621.1
UniProt Secondary Accession:Q15849,Q2TBD6, Q96PH5, A8K8Q7,
UniProt Related Accession:Q15849
Molecular Weight:
NCBI Full Name:urea transporter 2
NCBI Synonym Full Names:solute carrier family 14 (urea transporter), member 2
NCBI Official Symbol:SLC14A2  
NCBI Official Synonym Symbols:UT2; UTA; UTR; HUT2; UT-A2; hUT-A6  
NCBI Protein Information:urea transporter 2; urea transporter-2; urea transporter, kidney; solute carrier family 14 member 2
UniProt Protein Name:Urea transporter 2
UniProt Synonym Protein Names:Solute carrier family 14 member 2; Urea transporter, kidney
Protein Family:Urea transporter
UniProt Gene Name:SLC14A2  
UniProt Entry Name:UT2_HUMAN
Anti-SLC14A2 Antibody (CAB13208)Western blot analysis of extracts of various cell lines, using SLC14A2 antibody (CAB13208) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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