Cell Biology Antibodies 18

Anti-SLC12A3 Antibody (CAB18382)

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SKU:
CAB18382
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SLC12A3 Antibody
Antibody SKU:CAB18382
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human SLC12A3.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant protein of human SLC12A3.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6559
Uniprot:P55017
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:NCC, NCCT, TSC, SLC12A3
Background:
UniProt Protein Function:NCCT: Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption. Interacts with KLHL3. Predominant in kidney. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; cytosol

Molecular Function:protein binding; transporter activity; sodium:chloride symporter activity

Biological Process: transport; sodium ion transport; chloride transport; ion transport; transmembrane transport

Disease: Gitelman Syndrome

NCBI Summary:This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P55017
NCBI GenInfo Identifier:313104194
NCBI Gene ID:6559
NCBI Accession:P55017.3
UniProt Secondary Accession:P55017,A8MSJ2, C9JNN9,
UniProt Related Accession:P55017
Molecular Weight:113,808 Da
NCBI Full Name:Solute carrier family 12 member 3
NCBI Synonym Full Names:solute carrier family 12 (sodium/chloride transporter), member 3
NCBI Official Symbol:SLC12A3  
NCBI Official Synonym Symbols:NCC; TSC; NCCT  
NCBI Protein Information:solute carrier family 12 member 3; Na-Cl symporter; Na-Cl cotransporter; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; NaCl electroneutral thiazide-sensitive cotransporter
UniProt Protein Name:Solute carrier family 12 member 3
UniProt Synonym Protein Names:Na-Cl cotransporter; NCC; Na-Cl symporter; Thiazide-sensitive sodium-chloride cotransporter
UniProt Gene Name:SLC12A3  
UniProt Entry Name:S12A3_HUMAN
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