Signal Transduction Antibodies 1

Anti-SLC10A2 Antibody (CAB12846)

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SKU:
CAB12846
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SLC10A2 Antibody
Antibody SKU:CAB12846
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 289-348 of human SLC10A2 (NP_000443.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, Mouse small intestine, Mouse kidney, Rat small intestine, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 289-348 of human SLC10A2 (NP_000443.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FPLI YSIF QLAF AAIF LGFY VAYK KCHG KNKA EIPE SKEN GTEP ESSF YKAN GGFQ PDEK
Gene ID:6555
Uniprot:Q12908
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:37kDa
Observed MW:38kDa
Synonyms:SLC10A2, ASBT, IBAT, ISBT, NTCP2, PBAM
Background:This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG).
UniProt Protein Function:ASBT: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Defects in SLC10A2 are a cause of primary bile acid malabsorption (PBAM). PBAM is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 13q33.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:bile acid:sodium symporter activity

Biological Process: bile acid and bile salt transport; transport

Disease: Bile Acid Malabsorption, Primary

NCBI Summary:This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]
UniProt Code:Q12908
NCBI GenInfo Identifier:322510055
NCBI Gene ID:6555
NCBI Accession:Q12908.2
UniProt Secondary Accession:Q12908,Q13839, A1L4F4,
UniProt Related Accession:Q12908
Molecular Weight:38kDa
NCBI Full Name:Ileal sodium/bile acid cotransporter
NCBI Synonym Full Names:solute carrier family 10 member 2
NCBI Official Symbol:SLC10A2  
NCBI Official Synonym Symbols:ASBT; IBAT; ISBT; PBAM; NTCP2  
NCBI Protein Information:ileal sodium/bile acid cotransporter
UniProt Protein Name:Ileal sodium/bile acid cotransporter
UniProt Synonym Protein Names:Apical sodium-dependent bile acid transporter; ASBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; IBAT; ISBT; Na(+)-dependent ileal bile acid transporter; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2
Protein Family:Ileal sodium/bile acid cotransporter
UniProt Gene Name:SLC10A2  
Anti-SLC10A2 Antibody (CAB12846)Western blot analysis of extracts of various cell lines, using SLC10A2 antibody (CAB12846) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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