Name: Anti-SLC10A1 Antibody (CAB12721)
Brand: Immunology Antibodies 1
SKU: CAB12721
Availability: OutOfStock

Antibody Name:	Anti-SLC10A1 Antibody
Antibody SKU:	CAB12721
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human SLC10A1 (NP_003040.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse brain

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human SLC10A1 (NP_003040.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	VAVT VLSA INVG KSIM FAMT PLLI ATSS LMPF IGFL LGYV LSAL FCLN GRCR RTVS METG CQNV QLCS TILN VAFP PEVI GPLF FFPL LYMI FQLG EGLL LIAI FWCY EKFK TPKD KTKM IYTA ATTE ETIP GALG NGTY KGED CSPC TA
Gene ID:	6554
Uniprot:	Q14973
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	38kDa
Observed MW:	38kDa

Synonyms:

SLC10A1, NTCP

Background:

The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis.

UniProt Protein Function:	NTCP: The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 14q24.1 Cellular Component: integral to plasma membrane; basolateral plasma membrane; plasma membrane Molecular Function:bile acid:sodium symporter activity Biological Process: bile acid and bile salt transport; bile acid metabolic process; transport; sodium ion transport; transmembrane transport
NCBI Summary:	The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
UniProt Code:	Q14973
NCBI GenInfo Identifier:	2498046
NCBI Gene ID:	6554
NCBI Accession:	Q14973.1
UniProt Related Accession:	Q14973
Molecular Weight:
NCBI Full Name:	Sodium/bile acid cotransporter
NCBI Synonym Full Names:	solute carrier family 10 member 1
NCBI Official Symbol:	SLC10A1
NCBI Official Synonym Symbols:	NTCP
NCBI Protein Information:	sodium/bile acid cotransporter
UniProt Protein Name:	Sodium/bile acid cotransporter
UniProt Synonym Protein Names:	Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1
UniProt Gene Name:	SLC10A1
UniProt Entry Name:	NTCP_HUMAN

Western blot analysis of extracts of mouse brain, using SLC10A1 antibody (CAB12721) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

Antibodies

SLC10A1 Antibody (PACO02060)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)