Immunology Antibodies 2

Anti-SLAMF1 Antibody (CAB2044)

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SKU:
CAB2044
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-SLAMF1 Antibody
Antibody SKU:CAB2044
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-237 of human SLAMF1 (NP_003028.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Jurkat, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-237 of human SLAMF1 (NP_003028.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ASYG TGGR MMNC PKIL RQLG SKVL LPLT YERI NKSM NKSI HIVV TMAK SLEN SVEN KIVS LDPS EAGP PRYL GDRY KFYL ENLT LGIR ESRK EDEG WYLM TLEK NVSV QRFC LQLR LYEQ VSTP EIKV LNKT QENG TCTL ILGC TVEK GDHV AYSW SEKA GTHP LNPA NSSH LLSL TLGP QHAD NIYI CTVS NPIS NNSQ TFSP WPGC RTDP SETK P
Gene ID:6504
Uniprot:Q13291
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:33kDa/37kDa/40kDa
Observed MW:37kDa/65kDa
Synonyms:SLAMF1, CD150, CDw150, SLAM
Background:
UniProt Protein Function:SLAM: a type I membrane protein present on the surface of B cells, T cells and CD83+ dendritic cells. A high-affinity self-ligand considered to be important in bidirectional T <-> B-cell stimulation. SLAM-induced signal-transduction events in T lymphocytes are different from those in B cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A (SAP) acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (SHP-2)-dependent signal transduction operates. Its cytoplasmic domain interacts with SAP through part of its SH2 domain, and with SHP-2. Three alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: integral to membrane; phagocytic vesicle; external side of plasma membrane

Molecular Function:protein binding; transmembrane receptor activity; antigen binding

Biological Process: viral reproduction; regulation of catalytic activity; positive regulation of cell proliferation; regulation of vesicle fusion; lymphocyte activation; signal transduction

UniProt Code:Q13291
NCBI GenInfo Identifier:9297047
NCBI Gene ID:6504
NCBI Accession:Q13291.1
UniProt Secondary Accession:Q13291,Q5W172, Q9HBE8,
UniProt Related Accession:Q13291
Molecular Weight:335
NCBI Full Name:Signaling lymphocytic activation molecule
NCBI Synonym Full Names:signaling lymphocytic activation molecule family member 1
NCBI Official Symbol:SLAMF1  
NCBI Official Synonym Symbols:SLAM; CD150; CDw150  
NCBI Protein Information:signaling lymphocytic activation molecule; IPO-3
UniProt Protein Name:Signaling lymphocytic activation molecule
UniProt Synonym Protein Names:CDw150; IPO-3; CD_antigen: CD150
Protein Family:SLAM family
UniProt Gene Name:SLAMF1  
UniProt Entry Name:SLAF1_HUMAN
Anti-SLAMF1 Antibody (CAB2044)Western blot analysis of extracts of various cell lines, using SLAMF1 antibody (CAB2044) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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