Signal Transduction Antibodies 2
Anti-SLA Antibody (CAB17374)
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- SKU:
- CAB17374
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SLA Antibody |
| Antibody SKU: | CAB17374 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human SLA (NP_006739.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human SLA (NP_006739.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLSK LGHS PLGG LRAR LTFP VCLL YHRL WASP AAPG KKKE MGNS MKST PAPA ERPL PNPE GLDS DFLA VLSD YPSP DISP PIFR RGEK LRVI SDEG GWWK AISL STGR ESYI PGIC VARV YHGW LFEG LGRD KAEE LLQL PDTK VGSF MIRE SETK KGFY SLSV RHRQ VKHY RIFR LPNN WYYI SPRL TFQC LEDL VNHY SEVA DGLC CVLT TPCL TQST AAPA VRAS SSPV TLRQ KTVD WRRV SRLQ EDPE GTEN PLGV DESL FSYG LRES IASY |
| Gene ID: | 6503 |
| Uniprot: | Q13239 |
| Cellular Location: | |
| Calculated MW: | 31kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SLA1, SLAP, SLA |
| Background: |
| UniProt Protein Function: | SLAP: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 8q24 Cellular Component: endosome Molecular Function:protein binding; SH3/SH2 adaptor activity Biological Process: positive regulation of signal transduction |
| UniProt Code: | Q13239 |
| NCBI GenInfo Identifier: | 113930754 |
| NCBI Gene ID: | 6503 |
| NCBI Accession: | NP_001039021.1 |
| UniProt Secondary Accession: | Q13239,Q6FI01, Q9UMQ8, B7Z4J2, B7Z4L6, |
| UniProt Related Accession: | Q13239 |
| Molecular Weight: | 88 kDa |
| NCBI Full Name: | src-like-adapter isoform a |
| NCBI Synonym Full Names: | Src-like-adaptor |
| NCBI Official Symbol: | SLA |
| NCBI Official Synonym Symbols: | SLA1; SLAP |
| NCBI Protein Information: | src-like-adapter |
| UniProt Protein Name: | Src-like-adapter |
| UniProt Synonym Protein Names: | Src-like-adapter protein 1; SLAP-1; hSLAP |
| Protein Family: | SLAM family |
| UniProt Gene Name: | SLA |
| UniProt Entry Name: | SLAP1_HUMAN |
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