Epigenetics & Nuclear Signaling Antibodies 3

Anti-SIX3 Antibody (CAB17363)

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SKU:
CAB17363
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SIX3 Antibody
Antibody SKU:CAB17363
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human SIX3.
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Rat lung
Immunogen:Recombinant protein of human SIX3.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6496
Uniprot:O95343
Cellular Location:Nucleus
Calculated MW:35kDa
Observed MW:35kDa
Synonyms:SIX3, HPE2
Background:This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2.
UniProt Protein Function:SIX3: May be involved in visual system development. Defects in SIX3 are the cause of holoprosencephaly type 2 (HPE2). Holoprosencephaly (HPE) is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Belongs to the SIX/Sine oculis homeobox family.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2p21

Molecular Function:protein binding; transcription coactivator activity; transcription factor activity

Biological Process: brain development; cell proliferation in forebrain; epithelial cell maturation; eye development; forebrain dorsal/ventral pattern formation; lens development in camera-type eye; negative regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; neuroblast differentiation; pituitary gland development; protein import into nucleus, translocation; proximal/distal axis specification; regulation of cell proliferation; telencephalon development; telencephalon regionalization; visual perception

Disease: Holoprosencephaly 2; Schizencephaly

NCBI Summary:This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]
UniProt Code:O95343
NCBI GenInfo Identifier:6094293
NCBI Gene ID:6496
NCBI Accession:O95343.1
UniProt Secondary Accession:O95343,Q53T42, D6W5A5,
UniProt Related Accession:O95343
Molecular Weight:35,487 Da
NCBI Full Name:Homeobox protein SIX3
NCBI Synonym Full Names:SIX homeobox 3
NCBI Official Symbol:SIX3  
NCBI Official Synonym Symbols:HPE2  
NCBI Protein Information:homeobox protein SIX3
UniProt Protein Name:Homeobox protein SIX3
UniProt Synonym Protein Names:Sine oculis homeobox homolog 3
Protein Family:Homeobox protein
UniProt Gene Name:SIX3  
UniProt Entry Name:SIX3_HUMAN
Anti-SIX3 Antibody (CAB17363)Western blot analysis of extracts of various cell lines, using SIX3 antibody (CAB17363) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min.
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