Cell Biology Antibodies 9
Anti-SIRT3 Antibody (CAB5419)
(No reviews yet)
Write a Review
- SKU:
- CAB5419
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SIRT3 Antibody |
| Antibody SKU: | CAB5419 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-130 of human SIRT3 (NP_036371.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver, Mouse kidney, Mouse brain, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-130 of human SIRT3 (NP_036371.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ERVE AGGG VGPF QACG CRLV LGGR DDVS AGLR GSHG ARGE PLDP ARPL QRPP RPEV PRAF RRQP RAAA PSFF FSSI KGGR RSIS FSVG ASSV VGSG GSSD KGKL SLQD VAE |
| Gene ID: | 23410 |
| Uniprot: | Q9NTG7 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 28kDa/43kDa |
| Observed MW: | 30kDa |
| Synonyms: | SIRT3, SIR2L3, sirtuin 3 |
| Background: | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. |
| UniProt Code: | Q9NTG7 |
| NCBI GenInfo Identifier: | 38258651 |
| NCBI Gene ID: | 23410 |
| NCBI Accession: | Q9NTG7.2 |
| UniProt Secondary Accession: | Q9NTG7,Q9Y6E8, B7Z5U6, |
| UniProt Related Accession: | Q9NTG7 |
| Molecular Weight: | 399 |
| NCBI Full Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
| NCBI Synonym Full Names: | sirtuin 3 |
| NCBI Official Symbol: | SIRT3 |
| NCBI Official Synonym Symbols: | SIR2L3 |
| NCBI Protein Information: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial; sir2-like 3; sirtuin type 3; SIR2-like protein 3; regulatory protein SIR2 homolog 3; NAD-dependent deacetylase sirtuin-3, mitochondrial; silent mating type information regulation 2, S.cerevisiae, homolog 3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase |
| UniProt Protein Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
| UniProt Synonym Protein Names: | Regulatory protein SIR2 homolog 3; SIR2-like protein 3 |
| Protein Family: | NAD-dependent protein deacetylase sirtuin |
| UniProt Gene Name: | SIRT3 |
| UniProt Entry Name: | SIR3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SIRT3 antibody (CAB5419) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human prostate using SIRT3 antibody (CAB5419) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using SIRT3 antibody (CAB5419) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using SIRT3 antibody (CAB5419) at dilution of 1:100 (40x lens). |
View AllClose
Related Products
![Anti-SIRT3 Antibody (CAB5718)[KO Validated]](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/46227/50971/anti-sirt3-antibody-cab5718ko-validated__80340__20464.1706524764.jpg?c=1 "Anti-SIRT3 Antibody (CAB5718)[KO Validated]")
![Anti-SIRT3 Antibody [KO Validated] (CAB20805)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/78021/83203/anti-sirt3-antibody-ko-validated-cab20805__68257__11211.1706544946.jpg?c=1 "Anti-SIRT3 Antibody [KO Validated] (CAB20805)")
Anti-SIRT3 Antibody [KO Validated] (CAB20805)
OverviewAntibody Name:Anti-SIRT3 Antibody [KO Validated] (CAB20805)Antibody SKU:CAB20805Antibody Size:50µL, 100µLApplication:Western blotting, Immunohist
SIRT3 Monoclonal Antibody
OverviewProduct Name:SIRT3 Monoclonal AntibodyProduct Code:CAB22409Reactivity:Human, Mouse, RatApplications:Western blotting