Cell Biology Antibodies 9
Anti-SIGLEC5 Antibody (CAB4250)
(No reviews yet)
Write a Review
- SKU:
- CAB4250
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SIGLEC5 Antibody |
| Antibody SKU: | CAB4250 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 452-551 of human SIGLEC5 (NP_003821.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | K-562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 452-551 of human SIGLEC5 (NP_003821.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ICLC LIFF LIVK ARRK QAAG RPEK MDDE DPIM GTIT SGSR KKPW PDSP GDQA SPPG DAPP LEEQ KELH YASL SFSE MKSR EPKD QEAP STTE YSEI KTSK |
| Gene ID: | 8778 |
| Uniprot: | O15389 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 60kDa |
| Observed MW: | 140kDa |
| Synonyms: | SIGLEC5, CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5 |
| Background: | This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. |
| UniProt Protein Function: | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| NCBI Summary: | This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012] |
| UniProt Code: | O15389 |
| NCBI GenInfo Identifier: | 25009254 |
| NCBI Gene ID: | 8778 |
| NCBI Accession: | O15389.1 |
| UniProt Related Accession: | O15389 |
| Molecular Weight: | 60,715 Da |
| NCBI Full Name: | Sialic acid-binding Ig-like lectin 5 |
| NCBI Synonym Full Names: | sialic acid binding Ig like lectin 5 |
| NCBI Official Symbol: | SIGLEC5 |
| NCBI Official Synonym Symbols: | CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5 |
| NCBI Protein Information: | sialic acid-binding Ig-like lectin 5 |
| UniProt Protein Name: | Sialic acid-binding Ig-like lectin 5 |
| UniProt Synonym Protein Names: | CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD_antigen: CD170 |
| UniProt Gene Name: | SIGLEC5 |
 | Western blot analysis of extracts of K-562 cells, using SIGLEC5 antibody (CAB4250) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
View AllClose
Related Products
Cynomolgus SIGLEC5/CD170 Recombinant Protein (RPES2492)
system_update_altDatasheetCynomolgus SIGLEC5/CD170 Recombinant Protein Sialic acid-binding Ig-like lectin 5 is a protein that in Cynomolgus is encoded by the SIGLEC5 gene, Cynomolgus SIGLEC5 cDNA
Human SIGLEC5 ELISA Kit (HUFI06525)
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीकी
Human SIGLEC5 Recombinant Protein (RPES0697)
Cell Biology Recombinant Proteins
system_update_altDatasheetHuman SIGLEC5 Recombinant Protein SIGLEC5 contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. It belongs to the i
