Metabolism Antibodies 3
Anti-Sialidase-2 Antibody (CAB8137)
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- SKU:
- CAB8137
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | NEU2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8137 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 171-380 of human NEU2 (NP_005374.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 171-380 of human NEU2 (NP_005374.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ARSL VVPA YAYR KLHP IQRP IPSA FCFL SHDH GRTW ARGH FVAQ DTLE CQVA EVET GEQR VVTL NARS HLRA RVQA QSTN DGLD FQES QLVK KLVE PPPQ GCQG SVIS FPSP RSGP GSPA QWLL YTHP THSW QRAD LGAY LNPR PPAP EAWS EPVL LAKG SCAY SDLQ SMGT GPDG SPLF GCLY EAND YEEI VFLM FTLK QAFP AEYL PQ |
| Gene ID: | 4759 |
| Uniprot: | Q9Y3R4 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
| Synonyms: | NEU2, SIAL2 |
| Background: | This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. |
| UniProt Protein Function: | NEU2: Hydrolyzes sialylated compounds. Belongs to the glycosyl hydrolase 33 family. |
| UniProt Protein Details: | Protein type:EC 3.2.1.18; Hydrolase; Glycan Metabolism - other glycan degradation; Lipid Metabolism - sphingolipid Chromosomal Location of Human Ortholog: 2q37 Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; membrane Molecular Function:exo-alpha-sialidase activity; protein binding Biological Process: ganglioside catabolic process; glycosphingolipid metabolic process; oligosaccharide catabolic process |
| NCBI Summary: | This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y3R4 |
| NCBI GenInfo Identifier: | 229462907 |
| NCBI Gene ID: | 4759 |
| NCBI Accession: | Q9Y3R4.2 |
| UniProt Secondary Accession: | Q9Y3R4,Q3KNW4, Q6NTB4, |
| UniProt Related Accession: | Q9Y3R4 |
| Molecular Weight: | 42,254 Da |
| NCBI Full Name: | Sialidase-2 |
| NCBI Synonym Full Names: | neuraminidase 2 |
| NCBI Official Symbol: | NEU2 |
| NCBI Official Synonym Symbols: | SIAL2 |
| NCBI Protein Information: | sialidase-2 |
| UniProt Protein Name: | Sialidase-2 |
| UniProt Synonym Protein Names: | Cytosolic sialidase; N-acetyl-alpha-neuraminidase 2 |
| Protein Family: | Sialidase |
| UniProt Gene Name: | NEU2 |
| UniProt Entry Name: | NEUR2_HUMAN |
 | Western blot analysis of extracts of Raji cells, using NEU2 antibody (CAB8137) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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