Cell Biology Antibodies 5
Anti-SHTN1 Antibody (CAB15179)
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- SKU:
- CAB15179
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SHTN1 Antibody |
| Antibody SKU: | CAB15179 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SHTN1 (NP_001120683.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SHTN1 (NP_001120683.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNSS DEEK QLQL ITSL KEQA IGEY EDLR AENQ KTKE KCDK IRQE RDEA VKKL EEFQ KISH MVIE EVNF MQNH LEIE KTCR ESAE ALAT KLNK ENKT LKRI SMLY MAKL GPDV ITEE INID DEDS TTDT DGAA ETCV SVQC QKQI KELR DQIV SVQE EKKI LAIE LENL KSKL VEVI EEVN KVKQ EKTV LNSE VLEQ RKVL EKCN RVSM LAVE EYEE MQVN LELE KDLR KKAE SFAQ EMFI EQNK LKRQ SHLL LQSS IPDQ QLLK ALDE NAKL TQQL EEER IQHQ QKVK ELEE QLEN ETLH |
| Gene ID: | 57698 |
| Uniprot: | A0MZ66 |
| Cellular Location: | Cell projection, Cytoplasm, Perikaryon, axon, cytoskeleton, filopodium, growth cone, lamellipodium |
| Calculated MW: | 23kDa, 52- 73kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SHTN1, KIAA1598, shootin-1 |
| Background: |
| UniProt Protein Function: | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. |
| UniProt Code: | A0MZ66 |
| NCBI GenInfo Identifier: | 187761324 |
| NCBI Gene ID: | 57698 |
| NCBI Accession: | NP_001120683.1 |
| UniProt Secondary Accession: | A0MZ66,Q68DG1, Q6PIM5, Q9HCH4, A8MYU7, B3KRD3, B3KRH2 B3KTE0, B3KTJ7, B3KTJ8, B4E3U1, B7Z7Z9, |
| UniProt Related Accession: | A0MZ66 |
| Molecular Weight: | 23kDa, 52-73kDa |
| NCBI Full Name: | shootin-1 isoform a |
| NCBI Synonym Full Names: | shootin 1 |
| NCBI Official Symbol: | SHTN1 |
| NCBI Official Synonym Symbols: | KIAA1598; shootin-1 |
| NCBI Protein Information: | shootin-1 |
| UniProt Protein Name: | Shootin-1 |
| UniProt Synonym Protein Names: | Shootin1 |
| Protein Family: | Shootin |
| UniProt Gene Name: | SHTN1 |
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