Cell Biology Antibodies 12

Anti-SHOX2 Antibody (CAB8309)

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SKU:
CAB8309
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:SHOX2 Rabbit Polyclonal Antibody
Antibody SKU:CAB8309
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 96-355 of human SHOX2 (NP_003021.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:NCI-H460, Mouse skeletal muscle, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 96-355 of human SHOX2 (NP_003021.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ELDM GAAE RSRE PGSP RLTE GRRK PTKA EVQA TLLL PGEA FRFL VSPE LKDR KEDA KGME DEGQ TKIK QRRS RTNF TLEQ LNEL ERLF DETH YPDA FMRE ELSQ RLGL SEAR VQVW FQNR RAKC RKQE NQLH KGVL IGAA SQFE ACRV APYV NVGA LRMP FQQD SHCN VTPL SFQV QAQL QLDS AVAH AHHH LHPH LAAH APYM MFPA PPFG LPLA TLAA DSAS AASV VAAA AAAK TTSK NSSI ADLR LKAK KHAA ALGL
Gene ID:6474
Uniprot:O60902
Cellular Location:Nucleus
Calculated MW:33kDa/34kDa/37kDa
Observed MW:30kDa
Synonyms:SHOX2, OG12, OG12X, SHOT
Background:This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:SHOX2: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. Belongs to the paired homeobox family. Bicoid subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 3q25.32

Cellular Component: nucleoplasm; nuclear membrane; mitochondrion

Molecular Function:sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; nervous system development; heart development; negative regulation of transcription from RNA polymerase II promoter; chondrocyte development; osteoblast differentiation; positive regulation of skeletal muscle fiber development; embryonic digestive tract morphogenesis; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; positive regulation of axonogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of chondrocyte differentiation; skeletal development

NCBI Summary:This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
UniProt Code:O60902
NCBI GenInfo Identifier:89145413
NCBI Gene ID:6474
NCBI Accession:NP_006875
UniProt Related Accession:O60902
Molecular Weight:35kDa
NCBI Full Name:short stature homeobox protein 2 isoform a
NCBI Synonym Full Names:short stature homeobox 2
NCBI Official Symbol:SHOX2  
NCBI Official Synonym Symbols:OG12; SHOT; OG12X  
NCBI Protein Information:short stature homeobox protein 2
UniProt Protein Name:Short stature homeobox protein 2
UniProt Synonym Protein Names:Homeobox protein Og12X; Paired-related homeobox protein SHOT
Protein Family:Short stature homeobox protein
UniProt Gene Name:SHOX2  
UniProt Entry Name:SHOX2_HUMAN
Anti-SHOX2 Polyclonal Antibody (CAB8309)Western blot analysis of extracts of various cell lines, using SHOX2 antibody (CAB8309) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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