Anti-SHOX Antibody (CAB19517)
- SKU:
- CAB19517
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- SHOX
- Synonyms:
- GCFX
- Synonyms:
- PHOG
- Synonyms:
- SHOXY
- Synonyms:
- SS
Description
| Product Name: | SHOX Rabbit pAb |
| Product Code: | CAB19517 |
| Size: | 50uL |
| Synonyms: | SHOX, GCFX, PHOG, SHOXY, SS |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human SHOX |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, BxPC-3, Mouse brain, Rat heart |
| Immunogen: | A synthetic Peptide of human SHOX |
| Purification Method: | Affinity purification |
| Storage: | Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6473 |
| Uniprot: | O15266 |
| Cellular Location: | Nucleus |
| Calculated MW: | 25kDa/32kDa |
| Observed MW: | 32kDa |
| UniProt Protein Function: | SHOX: Controls fundamental aspects of growth and development. Defects in SHOX are the cause of Leri-Weill dyschondrosteosis (LWD). LWD is a dominantly inherited skeletal dysplasia characterized by moderate short stature predominantly because of short mesomelic limb segments. It is often associated with the Madelung deformity of the wrist, comprising bowing of the radius and dorsal dislocation of the distal ulna. Defects in SHOX are a cause of Langer mesomelic dysplasia (LMD). LMD is an autosomal recessive rare skeletal dysplasia characterized by severe short stature owing to shortening and maldevelopment of the mesomelic and rhizomelic segments of the limbs. Associated malformations are rarely reported and intellect is normal in all affected subjects reported to date. Defects in SHOX are a cause of idiopathic short stature (ISS). Idiopathic short stature is usually defined as a height below the third percentile for chronological age or minus 2 standard deviations of national height standards in the absence of specific causative disorders. Belongs to the paired homeobox family. Bicoid subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: Xp22.33;Yp11.3 Molecular Function:protein binding; transcription factor activity Biological Process: skeletal development; transcription from RNA polymerase II promoter Disease: Langer Mesomelic Dysplasia; Leri-weill Dyschondrosteosis; Short Stature, Idiopathic, Autosomal; Short Stature, Idiopathic, X-linked |
| NCBI Summary: | This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15266 |
| NCBI GenInfo Identifier: | 6831676 |
| NCBI Gene ID: | 6473 |
| NCBI Accession: | O15266.1 |
| UniProt Secondary Accession: | O15266,O00412, O00413, O15267, |
| UniProt Related Accession: | O15266 |
| Molecular Weight: | 25,501 Da |
| NCBI Full Name: | Short stature homeobox protein |
| NCBI Synonym Full Names: | short stature homeobox |
| NCBI Official Symbol: | SHOX |
| NCBI Official Synonym Symbols: | SS; GCFX; PHOG; SHOXY |
| NCBI Protein Information: | short stature homeobox protein |
| UniProt Protein Name: | Short stature homeobox protein |
| UniProt Synonym Protein Names: | Pseudoautosomal homeobox-containing osteogenic protein; Short stature homeobox-containing protein |
| Protein Family: | Short stature homeobox protein |
| UniProt Gene Name: | SHOX |
| UniProt Entry Name: | SHOX_HUMAN |
Related Products
