Name: Anti-SHFM1 Antibody (CAB18152)
Brand: Cell Biology Antibodies 14
SKU: CAB18152
Availability: OutOfStock

Antibody Name:	Anti-SHFM1 Antibody
Antibody SKU:	CAB18152
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant protein of human SHFM1.

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:

Immunogen:	Recombinant protein of human SHFM1.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	7979
Uniprot:	P60896
Cellular Location:
Calculated MW:
Observed MW:	Refer to figures

Synonyms:	C7orf76, DSS1, ECD, SHFD1, SHFM1, SHSF1, Shfdg1, SEM1
Background:

UniProt Protein Function:	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.
NCBI Summary:	The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008]
UniProt Code:	P60896
NCBI GenInfo Identifier:	5453640
NCBI Gene ID:	7979
NCBI Accession:	NP_006295.1
UniProt Secondary Accession:	P60896,Q13437, Q61067,
UniProt Related Accession:	P60896,Q6ZVN7
Molecular Weight:	8-10 kDa
NCBI Full Name:	26S proteasome complex subunit SEM1 isoform 3
NCBI Synonym Full Names:	SEM1, 26S proteasome complex subunit
NCBI Official Symbol:	SEM1
NCBI Official Synonym Symbols:	ECD; DSS1; SHFD1; SHFM1; SHSF1; Shfdg1; C7orf76
NCBI Protein Information:	26S proteasome complex subunit SEM1
UniProt Protein Name:	26S proteasome complex subunit SEM1
UniProt Synonym Protein Names:	26S proteasome complex subunit DSS1; Deleted in split hand/split foot protein 1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 protein
Protein Family:	Exoribonuclease
UniProt Gene Name:	SEM1