Neuroscience

Anti-SHC3 Antibody (CAB15453)

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SKU:
CAB15453
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Neuroscience

Description

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Antibody Name:Anti-SHC3 Antibody
Antibody SKU:CAB15453
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 310-450 of human SHC3 (NP_058544.3).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 310-450 of human SHC3 (NP_058544.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QCPT KIPA LHDR MQSL DEPW TEEE GDGS DHPY YNSI PSKM PPPG GFLD TRLK PRPH APDT AQFA GKEQ TYYQ GRHL GDTF GEDW QQTP LRQG SSDI YSTP EGKL HVAP TGEA PTYV NTQQ IPPQ AWPA AVSS AESS PRKD L
Gene ID:53358
Uniprot:Q92529
Cellular Location:
Calculated MW:51kDa/64kDa
Observed MW:Refer to figures
Synonyms:SHC3, N-Shc, NSHC, RAI, SHCC
Background:
UniProt Protein Function:SHC3: an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q22.1

Cellular Component: plasma membrane; cytosol

Molecular Function:signal transducer activity; protein binding; receptor tyrosine kinase binding; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; synaptic transmission, glutamatergic; central nervous system development; learning and/or memory; nerve growth factor receptor signaling pathway; Ras protein signal transduction; insulin receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

UniProt Code:Q92529
NCBI GenInfo Identifier:224586793
NCBI Gene ID:53358
NCBI Accession:NP_058544.3
UniProt Secondary Accession:Q92529,Q5T7I7, Q8TAP2, Q9UCX5,
UniProt Related Accession:Q92529
Molecular Weight:64,056 Da
NCBI Full Name:SHC-transforming protein 3
NCBI Synonym Full Names:SHC (Src homology 2 domain containing) transforming protein 3
NCBI Official Symbol:SHC3  
NCBI Official Synonym Symbols:RAI; NSHC; SHCC; N-Shc  
NCBI Protein Information:SHC-transforming protein 3; protein Rai; neuronal Shc; SH2 domain protein C3; SHC-transforming protein C; src homology 2 domain-containing transforming protein C3; src homology 2 domain-containing-transforming protein C3
UniProt Protein Name:SHC-transforming protein 3
UniProt Synonym Protein Names:Neuronal Shc; N-Shc; Protein Rai; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3
Protein Family:SHC-transforming protein
UniProt Gene Name:SHC3  
UniProt Entry Name:SHC3_HUMAN
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