Cardiovascular Antibodies
Anti-SHB Antibody (CAB15318)
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- SKU:
- CAB15318
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-SHB Antibody |
| Antibody SKU: | CAB15318 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human SHB (NP_003019.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HeLa, Mouse heart, Mouse liver, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human SHB (NP_003019.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PYEP EGQS VDSD SEST VSPR LRES KLPQ DDDR PADE YDQP WEWN RVTI PALA AQFN GNEK RQSS PSPS RDRR RQLR APGG GFKP IKHG SPEF CGIL GERV D |
| Gene ID: | 6461 |
| Uniprot: | Q15464 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein |
| Calculated MW: | 30kDa/55kDa |
| Observed MW: | 55kDa |
| Synonyms: | SHB, bA3J10.2 |
| Background: |
| UniProt Protein Function: | SHB: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 9p13.2 Cellular Component: cytosol Molecular Function:protein binding; SH3/SH2 adaptor activity Biological Process: signal transduction; vascular endothelial growth factor receptor signaling pathway |
| UniProt Code: | Q15464 |
| NCBI GenInfo Identifier: | 110816415 |
| NCBI Gene ID: | 6461 |
| NCBI Accession: | Q15464.2 |
| UniProt Secondary Accession: | Q15464,Q504U5, Q5VUM8, B9EGM0, D3DRQ5, |
| UniProt Related Accession: | Q15464 |
| Molecular Weight: | 30,703 Da |
| NCBI Full Name: | SH2 domain-containing adapter protein B |
| NCBI Synonym Full Names: | SH2 domain containing adaptor protein B |
| NCBI Official Symbol: | SHB |
| NCBI Official Synonym Symbols: | bA3J10.2 |
| NCBI Protein Information: | SH2 domain-containing adapter protein B |
| UniProt Protein Name: | SH2 domain-containing adapter protein B |
| Protein Family: | SH2 domain-containing adapter protein |
| UniProt Gene Name: | SHB |
| UniProt Entry Name: | SHB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SHB antibody (CAB15318) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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