Anti-SHANK3 Antibody (CAB20488)
- SKU:
- CAB20488
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PSAP2
- Synonyms:
- SCZD15
- Synonyms:
- PROSAP2
- Synonyms:
- SPANK-2
- Synonyms:
- DEL22q13.3
Description
| Product Name: | SHANK3 Rabbit pAb |
| Product Code: | CAB20488 |
| Size: | 50uL, 100uL |
| Synonyms: | PSAP2, SCZD15, PROSAP2, SPANK-2, DEL22q13.3 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SHANK3. |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant protein of human SHANK3. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 85358 |
| Uniprot: | Q9BYB0 |
| Calculated MW: | 184kDa |
| Observed MW: | 220KDa |
| Background: | This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. |
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