Cell Biology Antibodies 11
Anti-SH3GL1 Antibody (CAB7449)
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- SKU:
- CAB7449
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SH3GL1 Antibody |
| Antibody SKU: | CAB7449 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat, Monkey |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 219-368 of human SH3GL1 (NP_003016.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat, Monkey |
| Positive Samples: | COS-7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 219-368 of human SH3GL1 (NP_003016.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VDAQ LDYH RQAV QILD ELAE KLKR RMRE ASSR PKRE YKPK PREP FDLG EPEQ SNGG FPCT TAPK IAAS SSFR SSDK PIRT PSRS MPPL DQPS CKAL YDFE PEND GELG FHEG DVIT LTNQ IDEN WYEG MLDG QSGF FPLS YVEV LVPL PQ |
| Gene ID: | 6455 |
| Uniprot: | Q99961 |
| Cellular Location: | Cell projection, Cytoplasm, Early endosome membrane, Peripheral membrane protein, podosome |
| Calculated MW: | 34kDa/36kDa/41kDa |
| Observed MW: | 41kDa |
| Synonyms: | SH3GL1, CNSA1, EEN, SH3D2B, SH3P8 |
| Background: | This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | SH3GL1: Implicated in endocytosis. May recruit other proteins to membranes with high curvature. In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene. Belongs to the endophilin family. |
| UniProt Protein Details: | Protein type:Oncoprotein; Vesicle Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cell projection; early endosome membrane; cytoplasm; podosome; cell junction Molecular Function:identical protein binding; protein binding; GTPase binding; lipid binding; phosphatase binding Biological Process: central nervous system development; endocytosis; signal transduction Disease: Leukemia, Acute Myeloid |
| NCBI Summary: | This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | Q99961 |
| NCBI GenInfo Identifier: | 12643797 |
| NCBI Gene ID: | 6455 |
| NCBI Accession: | Q99961.1 |
| UniProt Secondary Accession: | Q99961,Q99668, B4DRA1, E7EVZ4, M0QZV5, |
| UniProt Related Accession: | Q99961 |
| Molecular Weight: | 368 |
| NCBI Full Name: | Endophilin-A2 |
| NCBI Synonym Full Names: | SH3-domain GRB2-like 1 |
| NCBI Official Symbol: | SH3GL1 |
| NCBI Official Synonym Symbols: | EEN; CNSA1; SH3P8; SH3D2B |
| NCBI Protein Information: | endophilin-A2; endophilin-2; SH3 domain protein 2B; EEN fusion partner of MLL; extra 11-19 leukemia fusion; SH3-containing Grb-2-like 1 protein; SH3 domain-containing GRB2-like protein 1; extra eleven-nineteen leukemia fusion gene protein |
| UniProt Protein Name: | Endophilin-A2 |
| UniProt Synonym Protein Names: | EEN fusion partner of MLL; Endophilin-2; Extra eleven-nineteen leukemia fusion gene protein; EEN; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1 |
| Protein Family: | Endophilin |
| UniProt Gene Name: | SH3GL1 |
| UniProt Entry Name: | SH3G1_HUMAN |
 | Western blot analysis of extracts of COS-7 cells, using SH3GL1 antibody (CAB7449) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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