Cell Biology Antibodies 18
Anti-SH2D3C Antibody (CAB18416)
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- SKU:
- CAB18416
Description
| Antibody Name: | Anti-SH2D3C Antibody |
| Antibody SKU: | CAB18416 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SH2D3C. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human SH2D3C. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10044 |
| Uniprot: | Q8N5H7 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | CHAT, NSP3, PRO34088, SHEP1, SH2D3C |
| Background: |
| UniProt Protein Function: | SHEP1: an adaptor protein linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. Directly links activated, tyrosine-phosphorylated Eph receptors to small Ras superfamily GTPases. Positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 9q34.11 Cellular Component: membrane; cytoplasm Molecular Function:protein binding; SH3/SH2 adaptor activity; guanyl-nucleotide exchange factor activity Biological Process: positive regulation of signal transduction; small GTPase mediated signal transduction; JNK cascade; positive regulation of GTPase activity |
| NCBI Summary: | This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q8N5H7 |
| NCBI GenInfo Identifier: | 74751027 |
| NCBI Gene ID: | 10044 |
| NCBI Accession: | Q8N5H7.1 |
| UniProt Secondary Accession: | Q8N5H7,Q5HYE5, Q5JU31, Q6UY42, Q8N6X3, Q9Y2X5, A8K5S8 E9PG48, |
| UniProt Related Accession: | Q8N5H7 |
| Molecular Weight: | 77,122 Da |
| NCBI Full Name: | SH2 domain-containing protein 3C |
| NCBI Synonym Full Names: | SH2 domain containing 3C |
| NCBI Official Symbol: | SH2D3C |
| NCBI Official Synonym Symbols: | CHAT; NSP3; SHEP1; PRO34088 |
| NCBI Protein Information: | SH2 domain-containing protein 3C; novel SH2-containing protein 3; SH2 domain-containing Eph receptor-binding protein 1 |
| UniProt Protein Name: | SH2 domain-containing protein 3C |
| UniProt Synonym Protein Names: | Novel SH2-containing protein 3; SH2 domain-containing Eph receptor-binding protein 1; SHEP1 |
| UniProt Gene Name: | SH2D3C |
| UniProt Entry Name: | SH2D3_HUMAN |
Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Research Area: |
Cell Biology |
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