Immunology Antibodies 2
Anti-SH2D1B Antibody (CAB16010)
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- SKU:
- CAB16010
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-SH2D1B Antibody |
| Antibody SKU: | CAB16010 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-132 of human SH2D1B (NP_444512.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-132 of human SH2D1B (NP_444512.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDLP YYHG RLTK QDCE TLLL KEGV DGNF LLRD SESI PGVL CLCV SFKN IVYT YRIF REKH GYYR IQTA EGSP KQVF PSLK ELIS KFEK PNQG MVVH LLKP IKRT SPSL RWRG LKLE LETF VNSN SDYV DVLP |
| Gene ID: | 117157 |
| Uniprot: | O14796 |
| Cellular Location: | |
| Calculated MW: | 9kDa/15kDa |
| Observed MW: |
| Synonyms: | SH2D1B, EAT2 |
| Background: |
| UniProt Protein Function: | Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling. In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation. |
| NCBI Summary: | By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | O14796 |
| NCBI GenInfo Identifier: | 23503051 |
| NCBI Gene ID: | 117157 |
| NCBI Accession: | O14796.2 |
| UniProt Secondary Accession: | O14796,Q5T0L1, Q8NI18, Q969K9, B2RBN6, |
| UniProt Related Accession: | O14796 |
| Molecular Weight: | 9,024 Da |
| NCBI Full Name: | SH2 domain-containing protein 1B |
| NCBI Synonym Full Names: | SH2 domain containing 1B |
| NCBI Official Symbol: | SH2D1B |
| NCBI Official Synonym Symbols: | EAT2 |
| NCBI Protein Information: | SH2 domain-containing protein 1B |
| UniProt Protein Name: | SH2 domain-containing protein 1B |
| UniProt Synonym Protein Names: | EWS/FLI1-activated transcript 2; EAT-2 |
| Protein Family: | SH2 domain-containing protein |
| UniProt Gene Name: | SH2D1B |
 | Immunofluorescence analysis of U2OS cells using SH2D1B antibody (CAB16010) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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