Cell Biology Antibodies 9

Anti-SH2B1 Antibody (CAB5564)

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SKU:
CAB5564
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SH2B1 Antibody
Antibody SKU:CAB5564
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 360-520 of human SH2B1 (NP_056318.2).
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:200 IF 1:20 - 1:50
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 360-520 of human SH2B1 (NP_056318.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DAQH VKAW VSDI QECL SPGP CPAT SPRP MTLP LAPG TSFL TREN TDSL ELSC LNHS ESLP SQDL LLGP SESN DRLS QGAY GGLS DRPS ASIS PSSA SIAA SHFD SMEL LPPE LPPR IPIE EGPP TGTV HPLS APYP PLDT PETA TGSF LFQG EPEG GEGD Q
Gene ID:25970
Uniprot:Q9NRF2
Cellular Location:Cytoplasm, Membrane, Nucleus
Calculated MW:70kDa/72kDa/79kDa
Observed MW:
Synonyms:SH2B1, PSM, SH2B
Background:This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.
UniProt Protein Function:SH2-B-beta: an adaptor protein that specifically activates JAK2 and serve as adapter proteins for JAK1, -2 and -3. YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytosol

Molecular Function:protein binding

Biological Process: blood coagulation

NCBI Summary:This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
UniProt Code:Q9NRF2
NCBI GenInfo Identifier:313104186
NCBI Gene ID:25970
NCBI Accession:Q9NRF2.3
UniProt Secondary Accession:Q9NRF2,Q96FK3, Q96SX3, Q9NRF1, Q9NRF3, Q9P2P7, Q9Y3Y3 A8K2R7,
UniProt Related Accession:Q9NRF2
Molecular Weight:72,188 Da
NCBI Full Name:SH2B adapter protein 1
NCBI Synonym Full Names:SH2B adaptor protein 1
NCBI Official Symbol:SH2B1  
NCBI Official Synonym Symbols:PSM; SH2B  
NCBI Protein Information:SH2B adapter protein 1
UniProt Protein Name:SH2B adapter protein 1
UniProt Synonym Protein Names:Pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 domain-containing protein 1B
Protein Family:SH2B adapter protein
UniProt Gene Name:SH2B1  
UniProt Entry Name:SH2B1_HUMAN
Anti-SH2B1 Antibody (CAB5564)Immunohistochemistry of paraffin-embedded rat kidney using SH2B1 Antibody (CAB5564) at dilution of 1:100 (40x lens).
Anti-SH2B1 Antibody (CAB5564)Immunohistochemistry of paraffin-embedded human esophageal cancer using SH2B1 Antibody (CAB5564) at dilution of 1:100 (40x lens).
Anti-SH2B1 Antibody (CAB5564)Immunohistochemistry of paraffin-embedded mouse spleen using SH2B1 Antibody (CAB5564) at dilution of 1:100 (40x lens).
Anti-SH2B1 Antibody (CAB5564)Immunofluorescence analysis of HeLa cells using SH2B1 antibody (CAB5564). Blue: DAPI for nuclear staining.
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