Cell Biology Antibodies 2
Anti-SGK2 Antibody (CAB12137)
(No reviews yet)
Write a Review
- SKU:
- CAB12137
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SGK2 Antibody |
| Antibody SKU: | CAB12137 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 228-367 of human SGK2 (NP_733794.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | BxPC-3, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 228-367 of human SGK2 (NP_733794.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LHGL PPFY SQDV SQMY ENIL HQPL QIPG GRTV AACD LLQS LLHK DQRQ RLGS KADF LEIK NHVF FSPI NWDD LYHK RLTP PFNP NVTG PADL KHFD PEFT QEAV SKSI GCTP DTVA SSSG ASSA FLGF SYAP EDDD ILDC |
| Gene ID: | 10110 |
| Uniprot: | Q9HBY8 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 41kDa/43kDa/47kDa |
| Observed MW: | 47kDa |
| Synonyms: | SGK2, H-SGK2, dJ138B7.2 |
| Background: | This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SGK2: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Highly expressed in liver, kidney and pancreas, and at lower levels in brain. Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser- 416), need to be phsphorylated for its full activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; AGC group; SGK family Chromosomal Location of Human Ortholog: 20q13.2 Cellular Component: cytosol; intracellular; nucleus Molecular Function:ATP binding; calcium channel regulator activity; chloride channel regulator activity; potassium channel regulator activity; protein serine/threonine kinase activity; sodium channel regulator activity Biological Process: cellular sodium ion homeostasis; peptidyl-serine phosphorylation; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell growth; regulation of cell proliferation; response to oxidative stress |
| NCBI Summary: | This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q9HBY8 |
| NCBI GenInfo Identifier: | 28558166 |
| NCBI Gene ID: | 10110 |
| NCBI Accession: | Q9HBY8.1 |
| UniProt Secondary Accession: | Q9HBY8,Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9UKG6, |
| UniProt Related Accession: | Q9HBY8 |
| Molecular Weight: | 43,977 Da |
| NCBI Full Name: | Serine/threonine-protein kinase Sgk2 |
| NCBI Synonym Full Names: | SGK2, serine/threonine kinase 2 |
| NCBI Official Symbol: | SGK2 |
| NCBI Official Synonym Symbols: | H-SGK2; dJ138B7.2 |
| NCBI Protein Information: | serine/threonine-protein kinase Sgk2 |
| UniProt Protein Name: | Serine/threonine-protein kinase Sgk2 |
| UniProt Synonym Protein Names: | Serum/glucocorticoid-regulated kinase 2 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | SGK2 |
| UniProt Entry Name: | SGK2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SGK2 antibody (CAB12137) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose
Related Products
