Cell Biology Antibodies 17
Anti-SGIP1 Antibody (CAB18507)
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- SKU:
- CAB18507
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SGIP1 Antibody |
| Antibody SKU: | CAB18507 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SGIP1. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human SGIP1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 84251 |
| Uniprot: | Q9BQI5 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | SGIP1 |
| Background: |
| UniProt Protein Function: | SGIP1: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Vesicle Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: AP-2 adaptor complex; clathrin-coated vesicle; coated pit; cytoplasm; plasma membrane Molecular Function:microtubule binding; phospholipid binding; protein binding; SH3 domain binding Biological Process: positive regulation of receptor-mediated endocytosis |
| NCBI Summary: | SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BQI5 |
| NCBI GenInfo Identifier: | 114152158 |
| NCBI Gene ID: | 84251 |
| NCBI Accession: | Q9BQI5.2 |
| UniProt Secondary Accession: | Q9BQI5,Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6 Q8IWC2, A6NL81, A6NLD1, |
| UniProt Related Accession: | Q9BQI5 |
| Molecular Weight: | 68,338 Da |
| NCBI Full Name: | SH3-containing GRB2-like protein 3-interacting protein 1 |
| NCBI Synonym Full Names: | SH3 domain GRB2 like endophilin interacting protein 1 |
| NCBI Official Symbol: | SGIP1 |
| NCBI Protein Information: | SH3-containing GRB2-like protein 3-interacting protein 1 |
| UniProt Protein Name: | SH3-containing GRB2-like protein 3-interacting protein 1 |
| UniProt Synonym Protein Names: | Endophilin-3-interacting protein |
| Protein Family: | SH3-containing GRB2-like protein 3-interacting protein |
| UniProt Gene Name: | SGIP1 |
| UniProt Entry Name: | SGIP1_HUMAN |
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