Name: Anti-SGCB Antibody (CAB6979)
Brand: Cell Biology Antibodies 10
SKU: CAB6979
Availability: OutOfStock

Antibody Name:	Anti-SGCB Antibody
Antibody SKU:	CAB6979
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 94-318 of human SGCB (NP_000223.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	SKOV3, Mouse heart, Mouse skeletal muscle, Rat heart

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 94-318 of human SGCB (NP_000223.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	PNGC DSME FHES GLLR FKQV SDMG VIHP LYKS TVGG RRNE NLVI TGNN QPIV FQQG TTKL SVEN NKTS ITSD IGMQ FFDP RTQN ILFS TDYE THEF HLPS GVKS LNVQ KAST ERIT SNAT SDLN IKVD GRAI VRGN EGVF IMGK TIEF HMGG NMEL KAEN SIIL NGSV MVST TRLP SSSS GDQL GSGD WVRY KLCM CADG TLFK VQVT SQNM GCQI SDNP CGNT H
Gene ID:	6443
Uniprot:	Q16585
Cellular Location:	Cell membrane, Cytoplasm, Single-pass type II membrane protein, cytoskeleton, sarcolemma
Calculated MW:	26kDa/34kDa
Observed MW:	45kDa

Synonyms:	SGCB, A3b, LGMD2E, SGC
Background:	This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.

UniProt Protein Function:	SGCB: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCB are the cause of limb-girdle muscular dystrophy type 2E (LGMD2E). LGMD2E is an autosomal recessive disorder. Belongs to the sarcoglycan beta/delta/gamma/zeta family.
UniProt Protein Details:	Protein type:Dystrophin complex; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q12 Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; integral to plasma membrane; cytoplasm; sarcoglycan complex; sarcolemma Biological Process: muscle development; cardiac muscle cell development; muscle fiber development Disease: Muscular Dystrophy, Limb-girdle, Type 2e
NCBI Summary:	This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]
UniProt Code:	Q16585
NCBI GenInfo Identifier:	13431857
NCBI Gene ID:	6443
NCBI Accession:	Q16585.1
UniProt Secondary Accession:	Q16585,O00661, B7Z635,
UniProt Related Accession:	Q16585
Molecular Weight:	318
NCBI Full Name:	Beta-sarcoglycan
NCBI Synonym Full Names:	sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
NCBI Official Symbol:	SGCB
NCBI Official Synonym Symbols:	A3b; SGC; LGMD2E
NCBI Protein Information:	beta-sarcoglycan; 43DAG; beta-SG; 43 kDa dystrophin-associated glycoprotein; limb girdle muscular dystrophy 2E (non-linked families); beta-sarcoglycan(43kD dystrophin-associated glycoprotein)
UniProt Protein Name:	Beta-sarcoglycan
UniProt Synonym Protein Names:	43 kDa dystrophin-associated glycoprotein; 43DAG; A3b
Protein Family:	Beta-sarcoglycan
UniProt Gene Name:	SGCB
UniProt Entry Name:	SGCB_HUMAN

	Western blot analysis of extracts of various cell lines, using SGCB antibody (CAB6979) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded human prostate using SGCB antibody (CAB6979) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human esophagus using SGCB antibody (CAB6979) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using SGCB antibody (CAB6979) at dilution of 1:100 (40x lens).