Cell Biology Antibodies 7
Anti-SFTPD Antibody (CAB1651)
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- SKU:
- CAB1651
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SFTPD Antibody |
| Antibody SKU: | CAB1651 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-220 of human SFTPD (NP_003010.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-220 of human SFTPD (NP_003010.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RDGR DGRE GPRG EKGD PGLP GAAG QAGM PGQA GPVG PKGD NGSV GEPG PKGD TGPS GPPG PPGV PGPA GREG PLGK QGNI GPQG KPGP KGEA GPKG EVGA PGMQ GSAG ARGL AGPK GERG VPGE RGVP GNTG AAGS AGAM GPQG SPGA RGPP GLKG DKGI PGDK GAKG ESG |
| Gene ID: | 6441 |
| Uniprot: | P35247 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space, surface film |
| Calculated MW: | 37kDa |
| Observed MW: | 37kDa |
| Synonyms: | SFTPD, COLEC7, PSP-D, SFTP4, SP-D |
| Background: | The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. |
| UniProt Protein Function: | SFTPD: Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. Belongs to the SFTPD family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 10q22.2-q23.1 Cellular Component: proteinaceous extracellular matrix; extracellular space; collagen; lysosome; endocytic vesicle; extracellular region Molecular Function:protein binding; carbohydrate binding Biological Process: receptor-mediated endocytosis; negative regulation of T cell proliferation; positive regulation of phagocytosis; defense response to bacterium; negative regulation of interleukin-2 biosynthetic process; innate immune response; respiratory gaseous exchange; surfactant homeostasis; macrophage chemotaxis; alveolus development; regulation of cytokine production |
| NCBI Summary: | The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P35247 |
| NCBI GenInfo Identifier: | 317373510 |
| NCBI Gene ID: | 6441 |
| NCBI Accession: | P35247.3 |
| UniProt Secondary Accession: | P35247,Q5T0M3, Q6FH08, Q86YK9, Q8TCD8, Q9UCJ2, Q9UCJ3 |
| UniProt Related Accession: | P35247 |
| Molecular Weight: | 37,728 Da |
| NCBI Full Name: | Pulmonary surfactant-associated protein D |
| NCBI Synonym Full Names: | surfactant protein D |
| NCBI Official Symbol: | SFTPD |
| NCBI Official Synonym Symbols: | SP-D; PSP-D; SFTP4; COLEC7 |
| NCBI Protein Information: | pulmonary surfactant-associated protein D |
| UniProt Protein Name: | Pulmonary surfactant-associated protein D |
| UniProt Synonym Protein Names: | Collectin-7; Lung surfactant protein D |
| UniProt Gene Name: | SFTPD |
| UniProt Entry Name: | SFTPD_HUMAN |
 | Western blot analysis of extracts of A-549 cells, using SFTPD antibody (CAB1651) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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