Epigenetics & Nuclear Signaling Antibodies 3
Anti-SFRS9 Antibody (CAB4242)
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- SKU:
- CAB4242
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-SFRS9 Antibody |
| Antibody SKU: | CAB4242 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human SFRS9 (NP_003760.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, HT-29, HepG2, Mouse spleen, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human SFRS9 (NP_003760.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSGW ADER GGEG DGRI YVGN LPTD VREK DLED LFYK YGRI REIE LKNR HGLV PFAF VRFE DPRD AEDA IYGR NGYD YGQC RLRV EFPR TYGG RGGW PRGG RNGP PTRR SDFR VLVS GLPP SGSW QDLK DHMR EAGD VCYA DVQK DGVG MVEY LRKE DMEY ALRK LDDT KFRS HEGE TSYI RVYP ERST SYGY SRSR SGSR GRDS PYQS RGSP HYFS PFRP Y |
| Gene ID: | 8683 |
| Uniprot: | Q13242 |
| Cellular Location: | Nucleus |
| Calculated MW: | 25kDa |
| Observed MW: | 26kDa |
| Synonyms: | SRSF9, SFRS9, SRp30c |
| Background: | The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. |
| UniProt Protein Function: | SFRS9: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. Belongs to the splicing factor SR family. |
| UniProt Protein Details: | Protein type:RNA-binding; Spliceosome; RNA splicing Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: nucleoplasm; nucleolus Molecular Function:protein binding; nucleotide binding Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA splice site selection; mRNA export from nucleus; negative regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription |
| NCBI Summary: | The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010] |
| UniProt Code: | Q13242 |
| NCBI GenInfo Identifier: | 3929377 |
| NCBI Gene ID: | 8683 |
| NCBI Accession: | Q13242.1 |
| UniProt Secondary Accession: | Q13242,Q52LD1, |
| UniProt Related Accession: | Q13242 |
| Molecular Weight: | 221 |
| NCBI Full Name: | Serine/arginine-rich splicing factor 9 |
| NCBI Synonym Full Names: | serine/arginine-rich splicing factor 9 |
| NCBI Official Symbol: | SRSF9 |
| NCBI Official Synonym Symbols: | SFRS9; SRp30c |
| NCBI Protein Information: | serine/arginine-rich splicing factor 9; SR splicing factor 9; pre-mRNA-splicing factor SRp30C; splicing factor, arginine/serine-rich 9 |
| UniProt Protein Name: | Serine/arginine-rich splicing factor 9 |
| UniProt Synonym Protein Names: | Pre-mRNA-splicing factor SRp30C; Splicing factor, arginine/serine-rich 9 |
| Protein Family: | Serine/arginine-rich splicing factor |
| UniProt Gene Name: | SRSF9 |
| UniProt Entry Name: | SRSF9_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SRSF9 antibody (CAB4242) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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