Developmental Biology
Anti-SFRP1 Antibody (CAB2911)
- SKU:
- CAB2911
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-SFRP1 Antibody |
| Antibody SKU: | CAB2911 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-314 of human SFRP1 (NP_003003.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:100 - 1:500 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | NCI-H460, 293T, SKOV3, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-314 of human SFRP1 (NP_003003.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SASE YDYV SFQS DIGP YQSG RFYT KPPQ CVDI PADL RLCH NVGY KKMV LPNL LEHE TMAE VKQQ ASSW VPLL NKNC HAGT QVFL CSLF APVC LDRP IYPC RWLC EAVR DSCE PVMQ FFGF YWPE MLKC DKFP EGDV CIAM TPPN ATEA SKPQ GTTV CPPC DNEL KSEA IIEH LCAS EFAL RMKI KEVK KENG DKKI VPKK KKPL KLGP IKKK DLKK LVLY LKNG ADCP CHQL DNLS HHFL IMGR KVKS QYLL TAIH KWDK KNKE FKNF MKKM KNHE CPTF QSVF K |
| Gene ID: | 6422 |
| Uniprot: | Q8N474 |
| Cellular Location: | Secreted |
| Calculated MW: | 35kDa |
| Observed MW: | 35kDa |
| Synonyms: | SFRP1, FRP, FRP-1, FRP1, FrzA, SARP2 |
| Background: | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. |
| UniProt Code: | Q8N474 |
| NCBI GenInfo Identifier: | 61216811 |
| NCBI Gene ID: | 6422 |
| NCBI Accession: | Q8N474.1 |
| UniProt Secondary Accession: | Q8N474,O00546, O14779, |
| UniProt Related Accession: | Q8N474 |
| Molecular Weight: | 314 |
| NCBI Full Name: | Secreted frizzled-related protein 1 |
| NCBI Synonym Full Names: | secreted frizzled-related protein 1 |
| NCBI Official Symbol: | SFRP1 |
| NCBI Official Synonym Symbols: | FRP; FRP1; FrzA; FRP-1; SARP2 |
| NCBI Protein Information: | secreted frizzled-related protein 1; SARP-2; sFRP-1; secreted apoptosis-related protein 2 |
| UniProt Protein Name: | Secreted frizzled-related protein 1 |
| UniProt Synonym Protein Names: | Secreted apoptosis-related protein 2; SARP-2 |
| Protein Family: | Secreted frizzled-related protein |
| UniProt Gene Name: | SFRP1 |
| UniProt Entry Name: | SFRP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SFRP1 antibody (CAB2911) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human stomach using SFRP1 antibody (CAB2911) at dilution of 1:50 (20x lens). |
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