Cell Biology Antibodies 17

Anti-SFPQ Antibody (CAB3494)

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SKU:
CAB3494
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SFPQ Antibody
Antibody SKU:CAB3494
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human SFPQ
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:A synthesized peptide derived from human SFPQ
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6421
Uniprot:P23246
Cellular Location:
Calculated MW:100kDa
Observed MW:
Synonyms:POMP100, PPP1R140, PSF
Background:
UniProt Protein Function:PSF: a proline-and glutamine-rich splicing factor. Essential pre-mRNA splicing factor required early in spliceosome formation. Seems to also bind DNA. The active complex is a heterotetramer of two 52 kDa and two 100 kDa subunits. Reported to be a PKC-alpha-binding protein in the cell nucleus. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:RNA splicing; RNA-binding; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nucleoplasm; nuclear matrix; cytoplasm; nucleus; paraspeckles; chromatin

Molecular Function:protein binding; histone deacetylase binding; nucleotide binding

Biological Process: alternative nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; RNA splicing; rhythmic process; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; DNA repair; mRNA processing; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; DNA recombination

UniProt Code:P23246
NCBI GenInfo Identifier:1709851
NCBI Gene ID:6421
NCBI Accession:P23246.2
UniProt Secondary Accession:P23246,P30808, Q5SZ71,
UniProt Related Accession:P23246
Molecular Weight:Calculated MW: 72kDa/76kDaObserved MW: 115kDa
NCBI Full Name:Splicing factor, proline- and glutamine-rich
NCBI Synonym Full Names:splicing factor proline/glutamine-rich
NCBI Official Symbol:SFPQ  
NCBI Official Synonym Symbols:PSF; POMP100; PPP1R140  
NCBI Protein Information:splicing factor, proline- and glutamine-rich; hPOMp100; 100 kDa DNA-pairing protein; PTB-associated splicing factor; PTB-associated-splicing factor; DNA-binding p52/p100 complex, 100 kDa subunit; protein phosphatase 1, regulatory subunit 140; polypyrimidine tract binding protein associated; polypyrimidine tract-binding protein-associated splicing factor; polypyrimidine tract-binding protein-associated-splicing factor; splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated)
UniProt Protein Name:Splicing factor, proline- and glutamine-rich
UniProt Synonym Protein Names:100 kDa DNA-pairing protein; hPOMp100; DNA-binding p52/p100 complex, 100 kDa subunit; Polypyrimidine tract-binding protein-associated-splicing factor; PSF; PTB-associated-splicing factor
Protein Family:Splicing factor
UniProt Gene Name:SFPQ  
UniProt Entry Name:SFPQ_HUMAN
Anti-SFPQ Antibody (CAB3494)Immunohistochemistry - SFPQ Rabbit mAb (CAB3494)
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