Epigenetics & Nuclear Signaling Antibodies 5

Anti-SF3B3 Antibody (CAB9624)

(No reviews yet) Write a Review
SKU:
CAB9624
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SF3B3 Antibody
Antibody SKU:CAB9624
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human SF3B3
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Mouse testis, Rat lung
Immunogen:A synthesized peptide derived from human SF3B3
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23450
Uniprot:Q15393
Cellular Location:
Calculated MW:136kDa
Observed MW:136KDa
Synonyms:RSE1, SAP130, SF3b130, STAF130
Background:This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
UniProt Protein Function:SF3B3: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Belongs to the RSE1 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Spliceosome; RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: nucleolus; nucleoplasm; nucleus; small nuclear ribonucleoprotein complex; spliceosome; U12-dependent spliceosome

Molecular Function:protein binding; RNA binding

Biological Process: mRNA processing; negative regulation of protein catabolic process; nuclear mRNA splicing, via spliceosome; protein complex assembly; RNA splicing; RNA splicing, via transesterification reactions

NCBI Summary:This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
UniProt Code:Q15393
NCBI GenInfo Identifier:116242787
NCBI Gene ID:23450
NCBI Accession:Q15393.4
UniProt Secondary Accession:Q15393,Q6NTI8, Q96GC0, Q9BPY2, Q9UFX7, Q9UJ29,
UniProt Related Accession:Q15393
Molecular Weight:44,606 Da
NCBI Full Name:Splicing factor 3B subunit 3
NCBI Synonym Full Names:splicing factor 3b subunit 3
NCBI Official Symbol:SF3B3  
NCBI Official Synonym Symbols:RSE1; SAP130; SF3b130; STAF130  
NCBI Protein Information:splicing factor 3B subunit 3
UniProt Protein Name:Splicing factor 3B subunit 3
UniProt Synonym Protein Names:Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130
Protein Family:Splicing factor
UniProt Gene Name:SF3B3  
UniProt Entry Name:SF3B3_HUMAN
Anti-SF3B3 Antibody (CAB9624)Western blot - SF3B3 Rabbit mAb (CAB9624)
View AllClose

0 Reviews

View AllClose

Related Products