Name: Anti-SF3B3 Antibody (CAB9624)
Brand: Epigenetics & Nuclear Signaling Antibodies 5
SKU: CAB9624
Availability: OutOfStock

Antibody Name:	Anti-SF3B3 Antibody
Antibody SKU:	CAB9624
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human SF3B3

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HepG2, Mouse testis, Rat lung

Immunogen:	A synthesized peptide derived from human SF3B3
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	23450
Uniprot:	Q15393
Cellular Location:
Calculated MW:	136kDa
Observed MW:	136KDa

Synonyms:

RSE1, SAP130, SF3b130, STAF130

Background:

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]

UniProt Protein Function:	SF3B3: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Belongs to the RSE1 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Spliceosome; RNA-binding; RNA splicing Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: nucleolus; nucleoplasm; nucleus; small nuclear ribonucleoprotein complex; spliceosome; U12-dependent spliceosome Molecular Function:protein binding; RNA binding Biological Process: mRNA processing; negative regulation of protein catabolic process; nuclear mRNA splicing, via spliceosome; protein complex assembly; RNA splicing; RNA splicing, via transesterification reactions
NCBI Summary:	This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
UniProt Code:	Q15393
NCBI GenInfo Identifier:	116242787
NCBI Gene ID:	23450
NCBI Accession:	Q15393.4
UniProt Secondary Accession:	Q15393,Q6NTI8, Q96GC0, Q9BPY2, Q9UFX7, Q9UJ29,
UniProt Related Accession:	Q15393
Molecular Weight:	44,606 Da
NCBI Full Name:	Splicing factor 3B subunit 3
NCBI Synonym Full Names:	splicing factor 3b subunit 3
NCBI Official Symbol:	SF3B3
NCBI Official Synonym Symbols:	RSE1; SAP130; SF3b130; STAF130
NCBI Protein Information:	splicing factor 3B subunit 3
UniProt Protein Name:	Splicing factor 3B subunit 3
UniProt Synonym Protein Names:	Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130
Protein Family:	Splicing factor
UniProt Gene Name:	SF3B3
UniProt Entry Name:	SF3B3_HUMAN