Epigenetics & Nuclear Signaling Antibodies 3

Anti-SF3A3 Antibody (CAB4465)

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SKU:
CAB4465
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SF3A3
Synonyms:
PRP9
Synonyms:
PRPF9
Synonyms:
SAP61
Synonyms:
SF3a60
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:SF3A3 Rabbit pAb
Product Code:CAB4465
Size:20uL, 50uL, 100uL
Synonyms:SF3A3, PRP9, PRPF9, SAP61, SF3a60
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 292-501 of human SF3A3 (NP_006793.1).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, NIH/3T3, Raji, Mouse heart, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 292-501 of human SF3A3 (NP_006793.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SLES LDTS LFAK NPKS KGTK RDTE RNKD IAFL EAQI YEYV EILG EQRH LTHE NVQR KQAR TGEE REEE EEEQ ISES ESED EENE IIYN PKNL PLGW DGKP IPYW LYKL HGLN INYN CEIC GNYT YRGP KAFQ RHFA EWRH AHGM RCLG IPNT AHFA NVTQ IEDA VSLW AKLK LQKA SERW QPDT EEEY EDSS GNVV NKKT YEDL KRQG LL
Gene ID:10946
Uniprot:Q12874
Cellular Location:Nucleus speckle
Calculated MW:58kDa
Observed MW:59KDa
UniProt Protein Function:SF3A3: subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
UniProt Protein Details:

Protein type:Spliceosome; Motility/polarity/chemotaxis; RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nucleoplasm; spliceosome; nuclear speck

Molecular Function:protein binding; zinc ion binding

Biological Process: nuclear mRNA 3'-splice site recognition; RNA splicing, via transesterification reactions; nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA processing

NCBI Summary:This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. [provided by RefSeq, Jul 2008]
UniProt Code:Q12874
NCBI GenInfo Identifier:17380310
NCBI Gene ID:10946
NCBI Accession:Q12874.1
UniProt Secondary Accession:Q12874,Q15460, Q5VT87, D3DPT5,
UniProt Related Accession:Q12874
Molecular Weight:501
NCBI Full Name:Splicing factor 3A subunit 3
NCBI Synonym Full Names:splicing factor 3a, subunit 3, 60kDa
NCBI Official Symbol:SF3A3  
NCBI Official Synonym Symbols:PRP9; PRPF9; SAP61; SF3a60  
NCBI Protein Information:splicing factor 3A subunit 3; SAP 61; spliceosome associated protein 61; spliceosome-associated protein 61; splicing factor 3a, subunit 3, 60kD; pre-mRNA splicing factor SF3a (60kD)
UniProt Protein Name:Splicing factor 3A subunit 3
UniProt Synonym Protein Names:SF3a60; Spliceosome-associated protein 61; SAP 61
UniProt Gene Name:SF3A3  
UniProt Entry Name:SF3A3_HUMAN
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