Epigenetics & Nuclear Signaling Antibodies 3

Anti-SF3A1 Antibody (CAB4399)

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SKU:
CAB4399
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SF3A1
Synonyms:
PRP21
Synonyms:
PRPF21
Synonyms:
SAP114
Synonyms:
SF3A120
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:SF3A1 Rabbit pAb
Product Code:CAB4399
Size:20uL, 50uL, 100uL
Synonyms:SF3A1, PRP21, PRPF21, SAP114, SF3A120
Applications:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 443-793 of human SF3A1 (NP_005868.1).
Applications:WB
Recommended Dilutions:WB 1:1000 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse lung, Rat brain, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 443-793 of human SF3A1 (NP_005868.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DRSI REKQ SDDE VYAP GLDI ESSL KQLA ERRT DIFG VEET AIGK KIGE EEIQ KPEE KVTW DGHS GSMA RTQQ AAQA NITL QEQI EAIH KAKG LVPE DDTK EKIG PSKP NEIP QQPP PPSS ATNI PSSA PPIT SVPR PPTM PPPV RTTV VSAV PVMP RPPM ASVV RLPP GSVI APMP PIIH APRI NVVP MPPS APPI MAPR PPPM IVPT AFVP APPV APVP APAP MPPV HPPP PMED EPTS KKLK TEDS LMPE EEFL RRNK GPVS IKVQ VPNM QDKT EWKL NGQV LVFT LPLT DQVS VIKV KIHE ATGM PAGK QKLQ YEGI FIKD SNSL AYYN MANG AVIH LALK ERGG RKK
Gene ID:10291
Uniprot:Q15459
Cellular Location:Nucleus
Calculated MW:81kDa/88kDa
Observed MW:130kDa
UniProt Protein Function:SF3A1: subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
UniProt Protein Details:

Protein type:RNA-binding; Nuclear receptor co-regulator; Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: nucleoplasm; spliceosome

Molecular Function:protein binding; RNA binding

Biological Process: nuclear mRNA 3'-splice site recognition; nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA processing

NCBI Summary:This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]
UniProt Code:Q15459
NCBI GenInfo Identifier:2498882
NCBI Gene ID:10291
NCBI Accession:Q15459.1
UniProt Related Accession:Q15459
Molecular Weight:
NCBI Full Name:Splicing factor 3A subunit 1
NCBI Synonym Full Names:splicing factor 3a subunit 1
NCBI Official Symbol:SF3A1  
NCBI Official Synonym Symbols:PRP21; PRPF21; SAP114; SF3A120  
NCBI Protein Information:splicing factor 3A subunit 1
UniProt Protein Name:Splicing factor 3A subunit 1
UniProt Synonym Protein Names:SF3a120; Spliceosome-associated protein 114; SAP 114
Protein Family:Splicing factor
UniProt Gene Name:SF3A1  
UniProt Entry Name:SF3A1_HUMAN
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