Cell Biology Antibodies 11

Anti-SETD6 Antibody (CAB7242)

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SKU:
CAB7242
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SETD6 Antibody
Antibody SKU:CAB7242
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 301-473 of human SETD6 (NP_001153777.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, Mouse liver, Mouse kidney, Rat brain, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 301-473 of human SETD6 (NP_001153777.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EPYP DNTD DTAD IQMV TVRE AALQ GTKT EAER HLVY ERWD FLCK LEMV GEEG AFVI GREE VLTE EELT TTLK VLCM PAEE FREL KDQD GGGD DKRE EGSL TITN IPKL KASW RQLL QNSV LLTL QTYA TDLK TDQG LLSN KEVY AKLS WREQ QALQ VRYG QKMI LHQL LELT S
Gene ID:79918
Uniprot:Q8TBK2
Cellular Location:Nucleus
Calculated MW:50kDa/53kDa
Observed MW:53kDa
Synonyms:SETD6
Background:This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:SETD6: Protein-lysine N-methyltransferase that specifically monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. Belongs to the SETD6 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Methyltransferase; Methyltransferase, protein lysine; EC 2.1.1.-

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function:NF-kappaB binding; protein binding; protein-lysine N-methyltransferase activity

Biological Process: inhibition of NF-kappaB transcription factor; peptidyl-lysine mono-methylation; regulation of inflammatory response

UniProt Code:Q8TBK2
NCBI GenInfo Identifier:308153495
NCBI Gene ID:79918
NCBI Accession:Q8TBK2.2
UniProt Secondary Accession:Q8TBK2,Q9H787, A8K380, B5ME38,
UniProt Related Accession:Q8TBK2
Molecular Weight:473
NCBI Full Name:N-lysine methyltransferase SETD6
NCBI Synonym Full Names:SET domain containing 6
NCBI Official Symbol:SETD6  
NCBI Protein Information:N-lysine methyltransferase SETD6; SET domain-containing protein 6
UniProt Protein Name:N-lysine methyltransferase SETD6
UniProt Synonym Protein Names:SET domain-containing protein 6
Protein Family:N-lysine methyltransferase
UniProt Gene Name:SETD6  
UniProt Entry Name:SETD6_HUMAN
Anti-SETD6 Antibody (CAB7242)Western blot analysis of extracts of various cell lines, using SETD6 antibody (CAB7242) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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