Cell Biology Antibodies 11
Anti-SETD3 Antibody (CAB8071)
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- SKU:
- CAB8071
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IP
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | SETD3 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8071 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IP |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SETD3 (NP_115609.2). |
| Application: | WB IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IP 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | H460, DU145, MCF7, Mouse heart |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SETD3 (NP_115609.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGKK SRVK TQKS GTGA TATV SPKE ILNL TSEL LQKC SSPA PGPG KEWE EYVQ IRTL VEKI RKKQ KGLS VTFD GKRE DYFP DLMK WASE NGAS VEGF EMVN |
| Gene ID: | 84193 |
| Uniprot: | Q86TU7 |
| Cellular Location: | Nucleus |
| Calculated MW: | 32kDa/33kDa/67kDa |
| Observed MW: | 70kDa |
| Synonyms: | SETD3, C14orf154 |
| Background: |
| UniProt Protein Function: | SETD3: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Belongs to the SETD3 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Methyltransferase, protein lysine; EC 2.1.1.43; Methyltransferase Chromosomal Location of Human Ortholog: 14q32.2 Cellular Component: nuclear chromatin Molecular Function:histone lysine N-methyltransferase activity (H3-K4 specific); transcription coactivator activity; histone lysine N-methyltransferase activity (H3-K36 specific) Biological Process: transcription, DNA-dependent; peptidyl-lysine di-methylation; positive regulation of transcription, DNA-dependent; peptidyl-lysine tri-methylation; histone H3-K4 methylation; peptidyl-lysine mono-methylation; positive regulation of muscle cell differentiation; histone H3-K36 methylation; positive regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | Q86TU7 |
| NCBI GenInfo Identifier: | 40068481 |
| NCBI Gene ID: | 84193 |
| NCBI Accession: | NP_115609.2 |
| UniProt Secondary Accession: | Q86TU7,Q0VAQ2, Q659C0, Q86TU8, Q96GY9, Q9H5U5, A0PJU3 A5PLP0, B4DZE8, |
| UniProt Related Accession: | Q86TU7 |
| Molecular Weight: | 67kDa |
| NCBI Full Name: | histone-lysine N-methyltransferase setd3 isoform a |
| NCBI Synonym Full Names: | SET domain containing 3 |
| NCBI Official Symbol: | SETD3 |
| NCBI Official Synonym Symbols: | C14orf154 |
| NCBI Protein Information: | histone-lysine N-methyltransferase setd3 |
| UniProt Protein Name: | Histone-lysine N-methyltransferase setd3 |
| UniProt Synonym Protein Names: | SET domain-containing protein 3 |
| Protein Family: | Histone-lysine N-methyltransferase |
| UniProt Gene Name: | SETD3 |
| UniProt Entry Name: | SETD3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SETD3 antibody (CAB8071) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunoprecipitation analysis of 200ug extracts of HeLa cells, using 3 ug SETD3 antibody (CAB8071). Western blot was performed from the immunoprecipitate using SETD3 antibody (CAB8071) at a dilition of 1:1000. |
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